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Persimmon leaf flavone extract, preparation method and application thereof

A technology of persimmon leaf flavonoids and extracts, which is applied in the fields of persimmon leaf flavonoids extracts and their preparation and use, can solve the problems of insulin deficiency, discount of insulin action, poor oral drug treatment effect, etc.

Active Publication Date: 2008-06-11
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 2) Relative lack of insulin: In some patients, the level of insulin does not decrease, but the effect of insulin is greatly reduced, that is, the efficiency of insulin work is reduced. Although there is a "golden key", but the effect is not great, it can also cause diabetes, which belongs to type 2 diabetes
This type of diabetes can be treated with oral drugs first to improve the working efficiency of insulin, but about 50% of patients with type 2 diabetes will gradually have poor oral drug therapy and finally have to accept insulin therapy

Method used

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  • Persimmon leaf flavone extract, preparation method and application thereof
  • Persimmon leaf flavone extract, preparation method and application thereof
  • Persimmon leaf flavone extract, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: Preparation of persimmon leaf flavonoid extract

[0056] Take 150Kg of dried persimmon leaves, add 3500L of water and decoct twice for 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.15 (60°C) to obtain 40kg of liquid extract, add 120L of ethanol until the alcohol content reaches 65 %, stand overnight, filter the supernatant for later use; wash the precipitate twice with 85% ethanol, collect the washing liquid, let it stand, absorb the supernatant and combine with the previous supernatant, recycle the ethanol, obtain 6kg of extract, add 80kg of water Dissolve, filter, and extract the filtrate 3 times with 120 L of ethyl acetate, combine the ethyl acetate liquid, reclaim ethyl acetate, add water to dissolve 4 kg of thick paste, put on a macroporous resin column (macroporous resin is a polyamide type), wash with water until The eluate was colorless, and then eluted with 75% ethanol, collected the el...

Embodiment 2

[0057] Embodiment 2: Preparation of persimmon leaf flavonoid extract

[0058] Take 350Kg of dried persimmon leaves, add 5500L of water and decoct 3 times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.18 (60°C) to obtain 100kg of liquid extract, add 450L of ethanol until the alcohol content reaches 80 %, stand overnight, filter the supernatant for later use; the precipitate is washed twice with 85% ethanol, collect the washing liquid, let stand, absorb the supernatant and merge with the previous supernatant, reclaim ethanol, and obtain 5.6kg of extract, add water 95kg was dissolved, filtered, and the filtrate was extracted 3 times with ethyl acetate 300L, the ethyl acetate liquid was combined, ethyl acetate was reclaimed, and 6 kg of thick paste was dissolved in water, and the macroporous resin column (macroporous resin was a polyamide type) was used to Wash with water until the eluent is colorless, then elute with 80%...

Embodiment 3

[0059] Embodiment 3: preparation contains the medicine or health product of persimmon leaf flavonoid extract

[0060] Take 500Kg of dried persimmon leaves, add 5500L of water and decoct twice for 2.5 hours each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.12 (60°C) to obtain 100kg of liquid extract, add 320L of ethanol until the alcohol content reaches 75 %, filter the supernatant for later use; the precipitate is washed twice with 75% ethanol, the washing liquid is collected, and the ethanol is recovered. The obtained extract is 11.6 kg, dissolved in 150 kg of water, filtered, and the filtrate is extracted 3 times with 320 L of ethyl acetate, combined with acetic acid Ethyl solution, ethyl acetate was recovered to obtain 14 kg of thick paste, dissolved in water, put on a macroporous resin column (the macroporous resin is AB-8 type), washed with water until the eluent was colorless, and then eluted with 55% ethanol until it was fr...

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Abstract

The invention relates to an extract of persimmon leaves which are rich in flavones and a process for preparation, and the usage for preparing medicaments and / or health products for preventing and / or curing glucose and lipid metabolism and the relative illness, wherein glucose and lipid metabolism and the relative illness comprise hyperglycemia, diabetes mellitus and metabolism syndrome. Pharmacological researches, animal in vivo experiments and clinical researches show that the extracts of persimmon leaves which are rich in flavones have obvious functions of decompression, antihyperglycemic and antihypelipidemic, clinical curative effects for curing metabolism syndrome of diabetes, hyperlipemia, and hypertension are precise, and a toxicity test shows that the toxicity of the extracts of persimmon leaves which are rich in flavones of the invention is lower, and the security is high.

Description

technical field [0001] The present invention relates to medicinal extracts derived from plant materials and their preparation methods and uses, in particular, to extracts rich in flavonoids from persimmon leaves (referred to as "persimmon leaf flavonoids extract", "persimmon leaf flavones") and preparation methods And the use for preparing medicines and / or health care products for preventing and / or treating diseases related to glucose and lipid metabolism, wherein the diseases related to glucose and lipid metabolism include hyperglycemia, diabetes and metabolic syndrome. Background technique [0002] Persimmon leaves are bitter in taste and cold in nature. It has the effects of lowering the breath, relieving asthma, quenching thirst, promoting body fluid, and treating sores, and has a wide range of pharmacological effects. Studies at home and abroad have shown that persimmon leaf preparations, persimmon leaf tea, persimmon leaf extracts and persimmon leaf flavonoid glycosid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61P3/10A61K127/00
Inventor 贝伟剑王正平罗杰利幼
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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