Busulfan sustained-release implantation agent for curing entity tumour
A technology of sustained-release implants and busulfan, applied in the field of medicine, can solve problems such as unclear effects, systemic toxic and side effects that limit clinical application, etc.
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Embodiment 1
[0068] Put the weighed (80mg) sustained-release excipient (polylactic acid (PLA) with a molecular weight of 15000-25000) into the container, add a certain amount of organic solvent to dissolve and mix (subject to full dissolution), then add 20 mg of white Disinfect, re-shake and dry in vacuo to remove organic solvents. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain a slow-release implant containing 20% busulfan. The release time of the sustained-release implant in physiological saline in vitro is 16-24 days, and the release time in mouse subcutaneous is 15-25 days.
Embodiment 2
[0070] Sustained-release implants were made according to the method described in Example 1, but the anti-cancer active ingredients contained were one of the following:
[0071] (A) 1% busulfan and 99% polylactic acid;
[0072] (B) 5% busulfan and 95% polylactic acid;
[0073] (C) 10% busulfan and 90% polylactic acid;
[0074] (D) 15% busulfan and 85% polylactic acid;
[0075] (E) 20% Busulfan and 80% Polylactic Acid.
Embodiment 3
[0077] Put the weighed (85mg) sustained-release excipient (PLGA with a molecular weight of 15000-25000, 50:50) into the container, add a certain amount of organic solvent to dissolve and mix (subject to complete dissolution), then add 15mg of Buxiao Ann, re-shake and vacuum-dry to remove organic solvents. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain a slow-release implant containing 15% busulfan. The release time of the slow-release implant in physiological saline in vitro is 20-26 days, and the release time in mouse subcutaneous is 22-28 days.
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Abstract
Description
Claims
Application Information
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