Method for preparing temperature sensitive sustained-release gel of chitosan fat complexes

A temperature-sensitive hydrogel, chitosan technology, applied in the directions of pharmaceutical formulations, drug delivery, etc., can solve problems such as staying, and achieve the effects of simple operation, improved sensitivity, and good economic development potential.

Inactive Publication Date: 2008-05-14
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zheng Jing et al. used free radical solution polymerization to synthesize carboxymethyl chitosan grafted N-isopropyl acrylamide copolymer with temperature sensitivity in aqueous solution, but only stayed at the temperature sensitivity, infrared spectrum and X Ray Diffraction Analysis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add chitosan (0.36g) into acetate buffer (0.1M, pH value 3.8, 18ml), stir evenly, add 5mg of doxorubicin, stir to dissolve (3000rpm), place in ice bath and continue to stir for 15min, αβ- Sodium glycerophosphate (40%, 3ml) was cooled in a refrigerator at 4°C for 15 minutes, then slowly added to the chitosan solution under stirring (3000 rpm), and continued stirring for 15 minutes to obtain chitosan temperature-sensitive doxorubicin sustained-release gel.

Embodiment 2

[0016] Add chitosan oleic acid complex (0.18g) into acetate buffer solution (0.15M, pH value 4.2, 18ml), stir evenly, add 2mg of doxorubicin, stir to dissolve (4000rpm), place in ice bath and continue stirring 20min, αβ-sodium glycerophosphate (45%, 3ml) was cooled in a 4°C refrigerator for 20min, then slowly added chitosan oleate solution under stirring (4000rpm), and continued stirring for 20min to obtain chitosan oleate Thermosensitive doxorubicin sustained-release gel.

Embodiment 3

[0018] Add chitosan linoleate complex (0.36g) into acetate buffer (0.2M, pH value 4.6, 18ml), stir evenly, add paclitaxel 5mg, stir to dissolve (3500rpm), place in ice bath and continue stirring for 30min , αβ-sodium glycerophosphate (50%, 2ml) was cooled in an ice bath for 30 minutes, then slowly added to the chitosan linoleic acid solution under stirring (3500 rpm), and continued to stir for 30 minutes to obtain chitosan linoleic acid Thermosensitive paclitaxel extended-release gel.

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PUM

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Abstract

The invention discloses a thermo-sensitive sustained-release material, in particular to a preparation method of a thermo-sensitive sustained-release gel of a chitosan lipid composite, belonging to the polymer material science field. The invention is characterized in that: the chitosan is prepared into a chitosan fatty acid lipid composite, and the thermo-sensitive sustained-release gel is prepared by the chitosan and the chitosan lipid; the gel is prepared by the main materials with the chitosan lipid composite and alpha-beta-sodium glycerophosphate, and a medicament carrier is used for in-situ injection and partial treatment. The invention has the advantages of strengthening partial treatment effect of antitumor drugs, avoiding the side effects and favorable prospect of study, development and utilization.

Description

technical field [0001] The invention relates to a chitosan and chitosan lipid temperature-sensitive slow-release gel in the field of pharmaceutical polymer materials, a preparation method of the gel, and a drug carrier for in-situ injection and local treatment. Background technique [0002] Early studies on thermosensitive hydrogels mainly focused on the synthesis of thermosensitive hydrogel materials, including polyethylene glycol / polypropylene glycol copolymers, polyethylene glycol / polybutylene glycol copolymers, polyacrylic acid and polyisocyanate. Preparation of a series of polymers with phase change properties such as acrylamide. However, most of these polymers are not biodegradable, which limits their clinical application; then there are alternative products that are biodegradable and injectable under physiological conditions, such as polyoxyethylene (PEG) and Polyoxyethylene (PEG) polymers such as polylactic acid (PLA) block copolymers and terpolymers (PEG-PLA-PEG) a...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/00
Inventor 陈西广周惠云刘成圣
Owner OCEAN UNIV OF CHINA
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