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Novel genes and proteins of brachyspira hyodysenteriae and use of same for diagnosis and therapy

A technology for swine dysentery and short helix, applied in genetic engineering, antibody medical ingredients, plant genetic improvement, etc., can solve problems such as disease deterioration

Inactive Publication Date: 2008-05-07
MURDOCH UNIV
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Problems solved by technology

However, none of the vaccination regimens tested conferred protection in mice against B. hyodysenteriae colonization and associated damage
Interestingly, inoculation of mice with DNA alone caused significant disease progression (Davis, A.J., Smith, S.C. and Moore, R.J. (2005). The Brachyspira hyodysenteriae ftn A gene: DNA vaccination and real-time PCR quantification of bacteria in a mouse model of disease. Current Microbiology 50: 285-291)

Method used

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Embodiment Construction

[0018] The articles "a" and "an" are used herein to refer to one or to more than one (ie to at least one) of the grammatical object of the article. For example "an element" means one element or more than one element.

[0019] The term "amino acid" is intended to include all molecules, whether natural or artificial, that contain amino functionality and acid functionality and are capable of inclusion within naturally occurring amino acid polymers. Exemplary amino acids include naturally occurring amino acids; analogs, derivatives and congeners thereof; amino acid analogs having variable side chains and stereoisomers of any of the foregoing.

[0020] An animal can be any mammal or bird. Examples of mammals include dogs, cats, hamsters, gerbils, rabbits, ferrets, horses, cows, sheep, pigs, monkeys and humans. Examples of birds include chickens, geese, ducks, turkeys and parrots.

[0021] The term "conserved residue" refers to an amino acid that is a member of a group of amino a...

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Abstract

The present invention describes novel polynucleotides and amino acids of B. hyodysenteriae. These sequences are useful for the diagnosis of B. hyodysenteriae in animals, and for the therapeutic or prophylactic treatment of B. hyodysenteriae in animals. These sequences may also be used in the diagnosis, and therapeutic and / or prophylactic treatment of diseases in animals caused by other Brachyspira species including Treponema, B. alvinipulli, B. alvinipulli, Brachyspira, Harmless Brachyspira, B. murdochii and Brachyspira pilosicoli.

Description

field of invention [0001] The present invention relates to novel genes of Brachyspira hyodysenteriae and proteins encoded therein. The present invention also relates to the use of these new genes and proteins for diagnosing B. hyodysenteriae disease, anti-B. hyodysenteriae vaccines, and screening compounds for killing B. hyodysenteriae or blocking the pathological effect of B. hyodysenteriae. These sequences may also be used for the diagnostic and therapeutic and / or prophylactic treatment of diseases in animals caused by other Brachyspira species including B. intermedia, B. intermedia, B. alvinipulli, B. aalborgi, B. innocens, B. murdochii and B. pilosicoli. Background of the invention [0002] Swine dysentery is a major endemic swine disease in Australia and worldwide. Swine dysentery is a mucohaemorrhagic diarrheal disease characterized by widespread inflammation and necrosis of the epithelial surface of the large intestine. Economic losses due to swine dysentery are ma...

Claims

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Application Information

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IPC IPC(8): C12N15/31C12N15/85C07K14/20C07K16/12C12Q1/68G01N33/53A61K39/02
CPCA61K2039/523A61K2039/53C07K14/20A61K39/00A61P31/04
Inventor M·贝尔伽德D·J·汉普森T·拉
Owner MURDOCH UNIV
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