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Nutritive composition for accelerating hemopoietic stem cell proliferation and hemoglobin synthesis

A nutritional composition and hematopoietic stem cell technology are applied in the field of nutritional compositions for medicine and health care, and can solve the problems of unsatisfactory health care effect of anemia, high recurrence, unavoidable side effects and the like

Active Publication Date: 2008-05-07
珍奥集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to iron deficiency, nutritional anemia is also related to the lack of folic acid, vitamins and other reasons, so the existing functional food has unsatisfactory health effects on anemia, and can only be used as supplementary food. high chance of recurrence
[0008] 2. Hematopoietic stem cell transplantation (HSCT) has two major problems of donor shortage and rejection
[0009] 3. Using gene therapy, there are still key issues to be solved to improve the transfection rate
[0010] 4. Exogenous delivery of EPO (erythropoietin) or androgen has unavoidable side effects

Method used

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  • Nutritive composition for accelerating hemopoietic stem cell proliferation and hemoglobin synthesis
  • Nutritive composition for accelerating hemopoietic stem cell proliferation and hemoglobin synthesis
  • Nutritive composition for accelerating hemopoietic stem cell proliferation and hemoglobin synthesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Nucleotides (bases or nucleosides or mononucleotides, oligonucleotides or polynucleotides, mixed nucleotides or ribonucleic acid or deoxyribonucleic acid, etc.), arginine, lysine, Cysteine, glycine, histidine, lecithin, cephalin, vitamin E, vitamin C, folic acid, vitamin B 2 , Vitamin B 6 , Vitamin B 12 , iron, zinc, manganese, wolfberry polysaccharide, grape seed extract (oligomeric anthocyanidin-GSPE, also known as proanthocyanidin) as raw materials, proportioned by weight, can be made into tablets, powders, oral liquids, Capsules etc. The amount of raw materials is calculated according to the concentration of active ingredients, etc., and the weight ratio of active ingredients should be ensured as follows: nucleotides 90-110, arginine 20-30, lysine 20-30, cysteine ​​10-20, glycine 25-35 , histidine 20-30, lecithin 110-130, cephalin 50-70, vitamin E0.4-0.6 (a-TE), vitamin C5-7, folic acid 0.02-0.04, vitamin B 2 0.05~0.07, Vitamin B 6 0.07~0.08, vitamin B 12 0...

Embodiment 2

[0049] Others are the same as in Example 1, the amount of raw materials is calculated according to the concentration, etc., and it should be ensured that the weight ratio of the final components is as follows: nucleotide 100, arginine 25, lysine 25, cysteine ​​15, glycine 30, histamine Acid 25, lecithin 120, cephalin 60, vitamin E0.5, vitamin C6, folic acid 0.03, vitamin B 2 0.06, vitamin B 6 0.06, vitamin B 12 0.0001, iron 1, zinc 0.6, manganese 0.5, wolfberry polysaccharide 15, grape seed extract 15. The dosage for the elderly with a body weight of 60 kg is based on 1000 mg of nucleotides.

[0050] Pharmacological effects:

[0051] 1. Create basic conditions for the proliferation of bone marrow hematopoietic stem cells

[0052] (1) Nucleotide supplementation (bases or nucleosides or mononucleotides, oligonucleotides or polynucleotides, mixed nucleotides or ribonucleic acid or deoxyribonucleic acid, etc.) not only It is helpful for gene replication, self-repair of damaged ...

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Abstract

The invention discloses a nutritional composition for promoting the proliferation of hematopoietic stem cells and the synthesis of haemoglobin. The invention is characterized in that the invention comprises raw materials and the proportion by weight as follows: 90 to 110 nucleotide, 20 to 30 parts of arginine, 20 to 30 parts of lysine, 10 to 20 parts of cysteine, 25 to 35 parts of glycin, 20 to 30 parts of histidine, 110 to 130 parts of lecithin, 50 to 70 parts of cephalin, 0.4 to 0.6 parts of vitamin E, 5 to 7 vitamin C, 0.02 to 0.04 parts of folacin, 0.05 to 0.07 parts of vitamin B2, 0.07 to 0.08 vitamin B6, 0.0001 to 0.0002 parts of vitamin B12, 0.5 to 1.5 parts of ferrum, 0.5 to 0.7 parts of zinc, 0.4 to 0.6 parts of manganese, 14 to 16 parts of boxthorn amylase, and 14 to 16 parts of grapestone aqueous extract. The invention can evidently improve the quantity of hemoglobins (Hb), red blood cells (RBC), white blood cells (WBC) and blood platelets (Plt) in the blood, can stimulate the proliferation of the marrow hematopoietic stem cells to lead the hematopoietic stem cells to be evidently increased, can evidently improve the number of mitochondrion in the cell and have obvious recovery function to the damage of liver and spleen.

Description

Technical field: [0001] The invention relates to a nutritional composition for medical and health care, in particular to a nutritional composition which can obviously promote the proliferation of hematopoietic stem cells and the synthesis of hemoglobin. Background technique: [0002] According to the World Health Organization (WHO) survey, there are about 3 billion people in the world with varying degrees of anemia, of which the incidence rate is about 10% in men and more than 20% in women. In the past 10 years, the incidence of various anemias including nutritional anemia has remained high in my country, and the incidence of anemia in modern urban residents has been increasing at a rate of 10% to 15% every year. [0003] In addition to nutritional anemia, according to the etiology and pathogenesis, anemia can also be divided into two categories: anemia caused by decreased red blood cell production and excessive destruction or loss of red blood cells. [0004] Anemia due to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P3/02A61P7/06A61K31/198A61K31/355A61K31/375A61K31/4172A61K31/4415A61K31/519A61K31/525A61K31/665A61K31/7052A61K31/714A61K31/715A61K33/26A61K33/30A61K33/32
Inventor 吴文国
Owner 珍奥集团股份有限公司
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