Temperature sensitive chitosan hydrogel
A chitosan and gel technology, applied in the field of chitosan hydrogel and its preparation, can solve the problems of increasing the patient's economic burden, pain, non-biodegradation, accelerated degradation, etc., and avoid organic chemical reagents and other harmful substances. , The effect of high temperature responsiveness and mild preparation conditions
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Embodiment 1
[0031] Dissolve 0.1 g of chitosan in 5 mL of 1mol / L glacial acetic acid solution and dissolve completely. 1.5 g glycerol was added. Add 3.4 mL of 15% (w / v) borax solution dropwise under stirring condition, and stir well to make it evenly mixed. The resulting solution had a pH of 7.0. The mixed solution was heated to 37°C and kept at a constant temperature for 20 minutes to fully gel the system. The system is stable at 4°C. Chitosan, glycerin, borax mixed solution, and photos of chitosan hydrogel gelled at 37°C figure 1 shown.
Embodiment 2
[0033] Dissolve 0.1 g of chitosan in 5 mL of 1mol / L glacial acetic acid solution and dissolve completely. 0.7 g of mannitol was dissolved in 3.7 mL of distilled water. Under the condition of stirring, 2.9 mL of 10% (w / v) borax solution was added dropwise, fully stirred to make it evenly mixed, and the pH value of the obtained solution was 7.0. The mixed solution was heated to 37°C and kept at a constant temperature for 20 minutes to fully gel the system. The system is stable at 4°C.
Embodiment 3
[0035] Dissolve 0.1 g of chitosan in 5 mL of 1mol / L glacial acetic acid solution and dissolve completely. 1.5 g glycerol was added. Add 3.4 mL of 15% (w / v) borax solution dropwise under stirring condition, and stir well to make it evenly mixed. Add 20% bovine serum albumin (BSA, model drug) to the mixed solution to dissolve, and mix evenly. The mixed solution containing bovine serum albumin was heated to 37°C and kept at a constant temperature for 20 minutes to fully gel the system. The system is stable at 4°C.
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