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Compound oral administration preparation with protective function to chemical liver injury

A technology for chemical liver injury and oral preparations, applied in the field of compound oral preparations, can solve problems such as unsuitable dosage for long-term use, difficulty in meeting health care needs, etc., so as to alleviate the pathological symptoms of liver injury, reduce content, and ensure reliability and stability Effect

Active Publication Date: 2008-03-19
SHANGHAI HUILUN BIOLOGICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most patients with liver diseases mainly rely on drug treatment. Some toxic substances of western medicine need to be eliminated by liver metabolism. The advantages are obvious, but the dosage of some components is not suitable for long-term use, and it is difficult to meet the health care needs of people's health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The following examples are used to further illustrate the present invention and are available for reference, but do not limit the scope of the present invention thereby. Embodiment 1 Tablet Preparation and Efficacy

[0018] The compound oral preparation of the present invention is tablet, 600mg / tablet.

[0019] Preparation of extract: The raw material ratio of Chinese medicinal materials is as follows:

[0020] Tangerine Peel 16% Salvia 10%

[0021] Hovenia dulcis 12% Angelica 8%

[0022] Rhodiola 12% Centella Asiatica 12%

[0023] Dried Ginger 10% Bupleurum 12%

[0024] Pueraria 8%

[0025] Take the above nine raw medicinal materials, select, wash, dry, and pulverize to make coarse powder; weigh the raw medicinal powder of each component according to the proportion, soak in water for 2 hours, add 10 times the amount and 8 times the amount of water to decoct 2 times, 2 hours each time, filter; combine the filtrates, concentrate under reduced pressure to an extract...

Embodiment 2

[0049] Embodiment 2 Granule preparation

[0050] The compound oral preparation of the present invention is a granule, 4g / bag.

[0051] The preparation of extract is the same as in Example 1.

[0052] Preparation of granules: Spray-dry the extract prepared above to make mist powder for later use, take 75% of the extract spray-dried powder, 5% of L-cysteine, 6.5% of vitamin C, and 0.5% of D-calcium pantothenate according to the proportioning ratio. %, 8% sucrose and 5% sodium carboxymethyl starch, fully mixed, made into granules, dried, and packed separately (4g / bag). The total flavonoid content (calculated as rutin) of the functional ingredients is 3.8mg / g.

[0053] Dosage: once a day, 1 bag each time.

Embodiment 3

[0054] Embodiment 3 capsule preparation

[0055] The compound oral preparation of the present invention is a capsule, 500mg / grain.

[0056] Preparation of the extract:

[0057] Tangerine Peel 18% Salvia 8%

[0058] Hovenia dulcis 14% Angelica 10%

[0059] Rhodiola 8% Centella Asiatica 10%

[0060] Dried Ginger 12% Bupleurum 10%

[0061] Pueraria 10%

[0062] Take the above nine raw medicinal materials, select, wash, dry, and pulverize to make coarse powder; weigh the raw medicinal powder of each component according to the proportion, soak in water for 2 hours, add 10 times the amount and 8 times the amount of water to decoct 2 times, 2 hours each time, filter; combine the filtrates, concentrate under reduced pressure to an extract with a relative density of 1.15-1.20, 60-70°C.

[0063] Preparation of capsules: Spray-dry the above-mentioned prepared extract to make mist powder for later use, take 68.3% of extract spray-dried powder, 7% of L-cysteine, 9% of vitamin C, 0.7% o...

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Abstract

The invention relates to a compound oral preparation, which has protective effect towards the chemical hepatic injury and the preparation method of the compound oral preparation. The compound oral preparation is various kinds of oral preparations comprise the main active components of a kudzuvine root, a Japanese raisin tree seed, a dry ginger, a dried tangerine peel, a rhodiola rosea, an Asiatic pennywort herb, a bupleurum root, a danshen root and an angelica and the officinal auxiliary materials. The invention is provided with reasonable prescription, advanced technology and convenient use and is safe and effective and is fit for being taken for a long time. The function test testifies that the preparation can obviously reduce the contents of serum glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase of an animal module with the hepatic injury caused by CCL4 and relieve the pathological symptoms of the hepatic injury; the preparation can not only be used as a good auxiliary treatment manner to the patient with the hepatitis but also can be used as health care product for normal people to take for a long time.

Description

Technical field: [0001] The invention relates to a compound oral preparation with protective effect on chemical liver damage, its preparation method and efficacy. Background technique: [0002] Chemical liver injury is liver injury caused by chemical hepatotoxic substances. These chemicals include alcohol, chemical poisons in the environment, and certain drugs, which can enter the liver through the gastrointestinal tract or systemic circulation for transformation, causing varying degrees of hepatic cell necrosis, steatosis, liver fibrosis, and cirrhosis. [0003] At present, most patients with liver diseases mainly rely on drug treatment. Some toxic substances of western medicine need to be eliminated by liver metabolism. The advantages are obvious, but the doses of certain components are not suitable for long-term administration, and it is difficult to meet the health care needs of people's health. Therefore, starting from prevention, taking into account health care funct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/14A61K9/16A61K9/20A61K9/48A61P1/16
Inventor 秦继红
Owner SHANGHAI HUILUN BIOLOGICAL TECH CO LTD
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