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Preparation method of 2,4-dichloro fluorobenzene

A technology of dichlorofluorobenzene and dichloronitrobenzene, which is applied in the field of fluorobenzene organic compounds, can solve the problems of difficulty and influence in the separation of intermediate fluorochloronitrobenzene isomers, and achieve High product quality, good operating environment and good reaction selectivity

Inactive Publication Date: 2008-03-05
浙江省常山长盛化工有限公司
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Problems solved by technology

This method can co-produce 2,6-dichlorofluorobenzene, but the disadvantage is that it is difficult to separate the isomers of the intermediate fluorochloronitrobenzene, which in turn affects the purity of 2,4-dichlorofluorobenzene

Method used

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  • Preparation method of 2,4-dichloro fluorobenzene
  • Preparation method of 2,4-dichloro fluorobenzene
  • Preparation method of 2,4-dichloro fluorobenzene

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Embodiment Construction

[0032] Embodiments of the present invention: the reaction process of the present invention is as follows:

[0033]

[0034] The whole reaction takes p-chloronitrobenzene as the starting material. Follow the steps below:

[0035] a. Using anhydrous ferric chloride as a catalyst, feed chlorine gas into the reaction kettle to react with p-chloronitrobenzene to generate 3,4-dichloronitrobenzene and hydrogen chloride. Hydrogen chloride is absorbed by water to obtain hydrochloric acid as a by-product. 3,4-Dichloronitrobenzene is washed with water and then rectified for the fluorination reaction in step b.

[0036] B, with 3,4-dichloronitrobenzene in the solvent DMF, the mixture that is 70%~90% with quaternary ammonium salt content and 10%~30% quaternary phosphonium salt content is used as catalyst, and Potassium Fluoride (FK ) generates 3-chloro-4-fluoronitrobenzene and potassium chloride at a temperature of 175-185°C, removes potassium chloride by filtration, and recovers sol...

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Abstract

The process of preparing 2, 4-dichlor fluorobenzene includes the following steps: 1. chloridizing parachloro nitrobenzene with chlorine to produce 3, 4-dichloro nitrobenzene; 2. dissolving 3, 4-dichloro nitrobenzene in solvent, and heating to produce fluoro reaction in the presence of catalyst to produce 3-chloro-4-fluoro nitrobenzene and potassium chloride; and 3. reacting 3-chloro-4-fluoro nitrobenzene and chlorine while heating and in the presence of catalyst to eliminate nitro group and produce 2, 4-dichlor fluorobenzene and nitro acyl chloride. The present invention has reasonable reaction path, cheap facile material, low cost, high reaction selectivity, high product quality and high safety.

Description

technical field [0001] The invention relates to a preparation method of fluorobenzene organic compounds, especially 2,4-dichlorofluorobenzene, belonging to the technical field of fluorine chemical industry. Background technique [0002] 2,4-Dichlorofluorobenzene is a colorless transparent or light yellow oily liquid. Freezing point: -23°C; Boiling point: 172-174°C; Density: 1.402-1.406 (25°C); Refractive index: 1.523-1.525 (25°C). [0003] It is mainly used for the main raw materials of antipsychotic drugs such as trihaloperidol, trihaloperidine, penfluridol, quinolones-ciprofloxacin, etc. It is also used for liquid crystals, pesticide intermediates, plastics, and resins Auxiliary. [0004] At present, the preparation methods of 2,4-dichlorofluorobenzene in China, according to the main routes of starting materials, are: fluorobenzene route, p-chloronitrobenzene route, 2,4-dinitrochlorobenzene route, ortho-dichlorobenzene route, etc. . [0005] [0006] The market pric...

Claims

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Application Information

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IPC IPC(8): C07C25/13C07C17/20C07C17/093
Inventor 陈志明周智慧徐德忠陈生荣丁小红裴文
Owner 浙江省常山长盛化工有限公司
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