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Traditional Chinese medicine compound preparations for treating respiratory disease and method for preparing the same

A compound preparation, respiratory technology, applied in respiratory diseases, antiviral agents, pharmaceutical formulations, etc., can solve problems such as large dosage, poor taste, and limited application.

Inactive Publication Date: 2008-03-05
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional dosage form of "Dayuan Drink" is water decoction, its quality cannot be controlled, and its preservation is low. Patients need to decoct and take a large amount of water decoction according to the doctor's advice. The dosage is large, especially for children who take too much medicine and are very inconvenient. The taste is poor, which limits its application and does not meet the market demand.
In order to give full play to the clinical efficacy of Dayuan Decoction, medical workers have done a lot of research on this classic formula, mainly focusing on its clinical pharmacological effects, but there is no such variety on the market at present.

Method used

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  • Traditional Chinese medicine compound preparations for treating respiratory disease and method for preparing the same
  • Traditional Chinese medicine compound preparations for treating respiratory disease and method for preparing the same
  • Traditional Chinese medicine compound preparations for treating respiratory disease and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Take raw material medicine by following proportioning ratio:

[0143] Betel nut 6 parts Magnolia officinalis 3 parts Grass nut 1.5 parts Anemarrhena 3 parts

[0144] 3 parts of white peony, 3 parts of skullcap, 1.5 parts of licorice

[0145] (1) For the above Qiwei raw materials, take grass nuts, add 12 times the amount of water, extract the volatile oil by steam distillation, collect the volatile oil, and set aside;

[0146] (2) Get Magnolia officinalis and extract with 75% ethanol, extract the solution to recover the solvent under reduced pressure, concentrate, dry, pulverize to obtain the extract and set aside;

[0147] (3) Take the herb nuts and Magnolia officinalis, add 12 times the amount of water, heat and extract 3 times, 1 hour each time, combine the water extracts, filter, concentrate the filtrate to 1.05, add 95% ethanol to contain alcohol The volume is 75%, placed, filtered, and the solvent is recovered under reduced pressure, diluted with water to a certa...

Embodiment 2

[0150] Take the raw material medicine according to the following proportioning ratio:

[0151] 5 parts of betel nut, 2.5 parts of Magnolia officinalis, 1.5 parts of grass nuts, 2.5 parts of Anemarrhena

[0152] 2.5 parts of white peony, 2.5 parts of skullcap, 1 part of licorice

[0153] Steps (1), (2) and (3) are the same as in Example 1, (4) the extracts in (2) and (3) are added with an appropriate amount of sucrose and dextrin, mixed evenly, made into granules, dried, and sprayed with ( 1) the volatile oil of the obtained grass nuts, and then prepare capsules according to a conventional process.

Embodiment 3

[0155] Take the raw material medicine according to the following proportioning ratio:

[0156] 6 parts of betel nut, 3 parts of magnolia, 1.5 parts of grass nut, 3 parts of anemarrhena, 3 parts of white peony

[0157] 3 parts of skullcap and 1.5 parts of licorice

[0158] (1) The above Qiwei raw materials are grass nuts, and supercritical carbon dioxide is used to extract volatile oil. The conditions are: extraction temperature is 50°C, pressure is 32Mpa, analysis temperature is 60°C, pressure is 6Mpa, and the average flow rate is 125kg / h. 0.5-4h, to get the volatile oil of grass nuts; after clathrate with β-cyclodextrin, dry to get clathrate;

[0159] (2) Get Magnolia officinalis and extract with 75% ethanol, extract the solution to recover the solvent under reduced pressure, concentrate, dry, pulverize to obtain the extract and set aside;

[0160] (3) Take the herb nuts and Magnolia officinalis, add 12 times the amount of water, heat and extract 3 times, 1 hour each time, ...

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Abstract

The present invention relates to one kind of compound Chinese medicine preparation for treating respiratory diseases and its preparation process. The compound Chinese medicine preparation is prepared with the materials including areca, official magnolia bark, tsaoko nut, anemarrhena, white peony root, skullcap root and licorice, and through distilling or supercritically extracting tsaoko nut to obtain volatile oil, extracting official magnolia bark with alcohol and concentrating and drying the extract, decocting the other Chinese medicinal materials and purifying the extract, mixing the extracts and the volatile oil, and further treatment to obtain the compound Chinese medicine preparation in different forms. The compound Chinese medicine preparation has the functions of clearing away heat, expelling surficial evil, relieving cough, resisting inflammation, resisting virus, etc. and possesses high curative effect, high bioavailability and other advantages.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine compound preparation for treating respiratory diseases and a preparation method thereof. Background technique [0002] Common respiratory diseases mainly include influenza, common cold, acute tracheo-bronchitis, acute exacerbation of chronic bronchitis, bacterial pneumonia, viral pneumonia and atypical pneumonia, etc. Respiratory viruses often cause severe epidemic diseases, The danger of atypical pneumonia (SARS) has attracted great attention from all over the world; influenza is an acute respiratory disease caused by influenza virus, and it is also a worldwide infectious disease that humans have not yet been able to effectively control. The clinical features are acute onset, short course of disease, high fever, fatigue, muscle aches all over the body, and mild respiratory symptoms. Influenza is highly contagious and can easily cause o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/00A61P11/00A61P31/16A61P31/14A61P31/04
Inventor 张铁军廖茂梁
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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