Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of alvianolic acid B salt as Na+/K+-ATP enzyme inhibitor

A salvianolic acid and application technology, applied in the application field of salvianolic acid B salt as Na+/K+-ATPase inhibitor, can solve the problems of narrow therapeutic dose index, easy to cause poisoning, etc.

Inactive Publication Date: 2008-03-05
JASON LIFE TECH
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention discloses a salvianolic acid B salt as a cell Na + / K + -The new use of ATPase inhibitors solves the problem of narrow therapeutic dose index of traditional cardiotonic glucoside drugs and easy to cause poisoning symptoms

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of alvianolic acid B salt as Na+/K+-ATP enzyme inhibitor
  • Use of alvianolic acid B salt as Na+/K+-ATP enzyme inhibitor
  • Use of alvianolic acid B salt as Na+/K+-ATP enzyme inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] Unless otherwise specified, the materials used in the examples of the present invention are all commercially available, wherein the magnesium salvianolic acid B comes from Jianian Biochemical Products Co., Ltd. (Taiwan), and the salvianolic acid B comes from Shanghai Huyun Pharmaceutical Development Co., Ltd. Company, ouabain comes from Sigma chemical company.

[0031] The invention discloses that salvianolic acid B salt can be used as Na + / K + -The new use of ATPase inhibitors, taking salvianolic acid B magnesium as an example, observing the effect of different concentrations of salvianolic acid B magnesium on the Na concentration of rat cardiomyocytes + / K + -ATPase activity inhibitory effect, its experimental operation steps are as follows:

[0032] Three-month-old male rats (Spraque-Dawley; Narl1: SD) were used as experimental animals and raised in a pathogen-free environment. During the breeding period, in addition to providing special feed for experimental an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention is the use of one kind of salvianolate B salt or its isomer, precursor, derivative, pharmaceutically acceptable salt and composition as Na+ / K+-ATP enzyme inhibitor. The Na+ / K+-ATP enzyme activity test on magnesium salvianolate B as one common salvianolate B salt proves that magnesium salvianolate B has suck structure as to be capable of substituting cyclopentahydrophenanathrene, as one kind of cardio-glucoside steroid medicine. The brain ischemia experiment proves the effect of magnesium salvianolate B in reducing injury on brain cell. All the said functions come from that salvianolate B salt can inhibit the hydrolysis of Na+ / K+-ATP enzyme actively transported phosphate radical to reduce the Na+ / K+ exchange of cell and increase calcium ions inside cell. The present invention has the uses of tonifying heart, promoting urination, protecting nerve cell, treating heart failure, etc.

Description

technical field [0001] The present invention relates to a new application of salvianolic acid B salt, or its isomers, precursors, derivatives, pharmaceutically acceptable salts or compositions containing it, especially for its role in inhibiting responsible cell Na + / K + Actively transported Na + / K + - Use of ATPases. Background technique [0002] Traditionally, various congestive heart failure, psychogenic shock and arrhythmia are mainly treated by using ouabain, digoxin and other cardiac glycoside preparations. The mechanism of action of these cardiotonic agents is to inhibit the myocardial cell Na + / K + -ATPase activity, thereby inhibiting cellular Na + / K + Active transport requires accompanying phosphate hydrolysis, reducing sodium and potassium ions passing through cardiomyocytes, making intracellular Na + Concentration increases, resulting in increased sodium-calcium exchange efficiency and increased inflow of calcium ions. Therefore, it can strengthen my...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/343A61K31/56A61P9/04A61P9/06A61P9/10A61P9/12A61P7/10
Inventor 靳子蓉陈怡菁曾志正陈志明
Owner JASON LIFE TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com