Pharmaceutical uses of black-seed grass-seed oil of tuberculate fruit

A technology of Nigella sativa seeds and medicine, which is applied in the field of medicinal use of Nigella sativa seed oil, and can solve problems such as insulin resistance and the like

Inactive Publication Date: 2008-02-27
新疆宝康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taghi-biglou et al. carried human apolipoprotein B (ApoB 100 ) but lacked brown adipose tissue in apolipoprotein B (ApoB) / brown adipose tissue (BAT)-deficient mice and fructose-fed hamster models found that increased hepatic VLDL-apolipoprotein B leads to Insulin resistance

Method used

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  • Pharmaceutical uses of black-seed grass-seed oil of tuberculate fruit
  • Pharmaceutical uses of black-seed grass-seed oil of tuberculate fruit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 10Kg of dried Nigella glandulifera Preyn., and use a conventional press to obtain Nigella glandulifera Preyn. oil.

Embodiment 2

[0022] Take 10Kg of dried Nigella, andulifera Preyn., pulverize, soak in petroleum ether at room temperature for 7 days, filter to remove the grass seeds, and use a rotary evaporator for the filtrate to remove the petroleum ether to obtain Nigella nigella seeds Oil.

Embodiment 3

[0024] Take 200 g of dry seeds of Nigella glandulifera Preyn., crush them, put them in a 2L flask with a stopper, put the flask into an ultrasonic extractor, and extract 3 times with petroleum ether at room temperature, 1.5L each time, soak The extraction time was 0.5 hours. The extracts were combined, filtered, and concentrated to dryness under reduced pressure in a rotary evaporator to obtain 75 g of an oily substance.

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PUM

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Abstract

The invention discloses a drug application of tumour-fruit black-seed grass-seed oil, which is characterized by the following: squeezing from tumour-fruit black-seed through normal method; extracting in the solvent; decompressing to remove solvent; testing the effect of protein tyrosine phosphatase 1B (PTP1B) inhibitor to resist lipid peroxidization and remove free radical of oxygen. The invention also provides an application in the antidiabetic drug and anti-oxidizing drug and health products.

Description

technical field [0001] The invention relates to the application of a Uyghur medicine commonly used medicinal material-Nigella nigella seed oil as a protein tyrosine phosphatase inhibitor drug, an anti-lipid peroxidation drug and a health care product. It has the effect of protein tyrosine phosphatase 1B (PTP1B) inhibitor and anti-lipid peroxidation effect confirmed by in vitro experiments. It forms the use of antidiabetic drugs and antioxidant drugs and health products. Background technique [0002] The Nigella genus belongs to the Ranunculaceae plant Nasturtium subfamily, among which there are three medicinal plants, namely: Nigella glandulifera Preyn., also known as Nigella glandulifera Preyn., and Nigella glandulifera (Nigella sativa), also known as Nigella sativa and Nigella damascena L., whose seeds are commonly used medicinal parts. At present, foreign research mainly focuses on Nigella sativa. Nigella glandulifera Frey (NG), native to the Mediterranean coast and Ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P3/10A61P39/06A61K131/00
Inventor 信学雷阿吉艾克拜尔·艾萨阿布力米提·伊力吴汉夔
Owner 新疆宝康药业有限公司
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