Plant extract and preparation with antitumor efficacy

A technology for extracts and pharmaceutical preparations, applied in the field of solanine extracts and preparations

Inactive Publication Date: 2008-02-20
杨石
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of solanine in Australia to anti-tumor drugs. There is no prepar...

Method used

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  • Plant extract and preparation with antitumor efficacy
  • Plant extract and preparation with antitumor efficacy
  • Plant extract and preparation with antitumor efficacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 Preparation method of Australian solanine extract

[0056] Take the whole herb and / or fruit of Solanum nigrum or the fresh fruit of Solanaceae chrysanthemum or Australian solanum, add 50% to 90% ethanol solution to extract 2 to 3 times, each time 6 to 8 times the amount, recover the ethanol, concentrate to relative density 1.25, add 2 to 4 times the amount of 0.1mol / l acidic solution to the concentrated solution, stir fully, refrigerate, filter, wash the filter residue with hydrochloric acid solution for 1 to 3 times, combine the filtrate and washing liquid, and use weak polarity or medium polarity Resin adsorption. After the resin is adsorbed, first wash the resin column / bed with water until the effluent is nearly neutral; then wash the resin column / bed with 0.1mol / l alkaline solution until the effluent is nearly colorless, and then use 30%-40% ethanol solution Flush the resin column / bed until the effluent is nearly colorless. discarded. Then elute with...

Embodiment 2

[0060] Example 2 Tablet preparation

[0061] Weigh 1000g of solanine extract with more than 90% solanine content and 1000g of medicinal starch, mix them evenly, granulate with starch slurry, dry and granulate, and press into tablets, each tablet contains 100mg of solanine.

Embodiment 3

[0062] Example 3 Preparation of capsules

[0063] Weigh 1000g of solanine extract with a solanine content of more than 90%, and 1000g of medicinal starch, mix them evenly, and put them into No. 2 capsules, each containing 100mg of solanine.

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Abstract

The present invention discloses a solanum nigrum whole plant and/ or fruit or Solanaceae plant Solanum xanthocarpum or Australian nightshade fresh fruit extract, the preparation and the preparation method, wherein, the extract has significant anti-tumor efficacy, safe use and low side effects. The content of solasonine is more than 90 percent in the solasonine extract. The solasonine extract pharmaceutical preparation of the present invention contains 1 percent to 99 percent solasonine extract with the solasonine content of 90 percent to 99 percent and 99 percent to 1 percent pharmaceutical excipients (including the drugs for other compatibility), while 25 percent to 85 percent solasonine extract with the solasonine content of 90 percent to 99 percent and 75 percent to 15 percent pharmaceutical excipients (including the drugs for other compatibility) is preferential, and the best is that the preparation contains 50 percent to 65 percent solasonine extract with the solasonine content of 90 percent to 99 percent and 35 percent to 50 percent pharmaceutical excipients (including the drugs for other compatibility). The pharmacologic experimental results show that the extract has better anti-tumor effect and easy use. The present invention has advanced technique, high content of the active ingredients, strong industrial practicability and relatively low cost.

Description

technical field [0001] The invention relates to the solanine extract and preparation of the whole herb and / or fruit of Solanum nigrum or the fresh fruit of Solanum solanum or Solanum australis for treating tumors, and belongs to the field of traditional Chinese medicine. Background technique [0002] Cancer has become one of the main problems threatening human life and health in modern society. According to the report of the World Health Organization (WHO), according to the current trend of cancer incidence, the incidence of cancer in the world will increase by 50% in 2020, and new cancers will be added every year in the world. The number of patients will reach 15 million. The medical community urgently needs safe and effective cancer treatment drugs. [0003] Solanine is found in many plants of the genus Solanaceae. Traditionally, many plants in this genus have been used to treat cancer, such as Solanum nigrum and Baiying. Steroidal glycoside compounds in plants have good...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P35/00C07G5/00
Inventor 杨石
Owner 杨石
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