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Antineoplastic active ferrum complex and method for preparing same

An anti-tumor activity, iron complex technology, applied in the direction of anti-tumor drugs, iron-organic compounds, drug combinations, etc., to achieve the effect of excellent liver cancer inhibition effect

Inactive Publication Date: 2008-01-30
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-heavy metal complexes, especially iron-containing enzyme-like compounds that can mimic the function of non-heme oxygen-activating enzymes in the body, have not been reported in China in the application of anti-tumor

Method used

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  • Antineoplastic active ferrum complex and method for preparing same
  • Antineoplastic active ferrum complex and method for preparing same
  • Antineoplastic active ferrum complex and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0048] 1. Synthesis of iron complexes

[0049] Drop 5ml of acetonitrile solution containing 1mmol of 2-chloromethylpyridine into a round-bottomed flask containing 1mmol of dipyridylamine in 20ml of acetonitrile solution, and stir at room temperature for 3 hours; distill to dryness to obtain a yellow oil, and recover 20ml of acetonitrile . Then use 20ml CH 2 Cl 2 Extract, wash with 10ml of saturated sodium sulfate and 10ml of water, separate with a separatory funnel, and discard the aqueous layer. 20mlCH 2 Cl 2 The solution was placed in a 50ml Erlenmeyer flask, dried with anhydrous sodium sulfate, filtered, and the solvent was distilled off to obtain trippicolylamine (L) as a yellow oil.

[0050] The synthesized tripyridylamine was mixed with 1mmol FeCl 3 , 10mL methanol solution, stir at room temperature for 2 hours, add 1mmol NaBPh 4 A dark red precipitate was obtained. Filtrate, wash the precipitate with a small amount of water and ethanol, and dry in vacuum to obta...

Embodiment 3

[0053] 1. Synthesis of iron complexes

[0054] Drop 5ml of acetonitrile solution containing 1mmol of 2-chloromethylpyridine into a round-bottomed flask containing 1mmol of dipyridylamine in 20ml of acetonitrile solution, stir at 50°C for 2 hours; distill to dryness to obtain a yellow oil, recover 20ml Acetonitrile. Then use 20ml CH 2 Cl 2 Extract, wash with 10ml of saturated sodium sulfate and 10ml of water, separate with a separatory funnel, and discard the aqueous layer. 20mlCH 2 Cl 2 The solution was placed in a 50ml Erlenmeyer flask, dried with anhydrous sodium sulfate, filtered, and the solvent was distilled off to obtain trippicolylamine (L) as a yellow oil.

[0055] The synthesized tripyridylamine was mixed with 1mmol FeCl 3 , 10mL methanol solution, react at 60°C for 0.5 hours, add 1mmol NaBPh 4 A dark red precipitate was obtained. Filtrate, wash the precipitate with a small amount of water and ethanol, and dry in vacuum to obtain a dark red powder. The dark re...

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Abstract

An anti-tumor activated ferric complex and preparation method thereof relate to complex preparation technique field. Dipyridylmethyl amine and 2-chrolomethylpyridine are used as materials, and react under the temperature condition of 20-80 DEG C for 1-3hours in acetonitrile solution according to 1:1 molar ratio between dipyridylmethyl amine and 2-chrolomethylpyridine, to prepare tripyridylmethyl amine (ligand L), then the combined tripyridylmethyl amine (L) is mixed with ferric trichroride and sodium tetraphenylborate in methanol solution and the molar ratio of tripyridylmethyl amine: ferric trichroride: sodium tetraphenylborate is 1: 1: 1, and stirred under the condition of 20-60 DEG C for 0.5-2 hours, finally oxygen-bridged dinuclear Fe(III) complex is synthesized : [LFeClOFeClOL]BPh4. The novel Fe (III) complex synthesized by the invention has excellent inhibitory effect to liver cancer.

Description

technical field [0001] The invention relates to the technical field of preparation of complexes, in particular to an anti-tumor active iron complex and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases that seriously endanger human health. Finding anti-tumor drugs with high efficiency and low toxicity has always been the goal of human unremitting struggle. Synthesizing and discovering highly effective and low-toxic antitumor drugs, studying their mechanism of action, and studying the causes of cancer at the molecular and cellular levels are of great significance in the fields of medicine, biology, and chemistry. The earliest reports on the antitumor activity of metal complexes can be traced back to the 16th century, but it was not until the discovery of the antitumor activity of the inorganic complex cisplatin in the 1960s that it aroused people's interest in other types of non-organic cytostatic drugs. Research has generated gr...

Claims

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Application Information

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IPC IPC(8): C07F15/02A61K31/555A61P35/00
Inventor 陈秋云刘青山
Owner JIANGSU UNIV
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