Aceclofenac in extended-released tablets and method of manufacturing the same
A technology for aceclofenac and sustained-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of hematopoiesis, ulcers or perforations in the upper gastrointestinal tract, and no aceclofenac sustained-release has yet been seen. Reports on research and development of tablets, gastrointestinal irritation, etc.
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Embodiment 1
[0035] The prescription for each tablet is as follows:
[0036] Aceclofenac 200mg
[0037] Hydroxypropyl Methyl Cellulose (HPMC K4M) 86mg
[0038] 14% (W / V) PVP K-30 alcohol solution 50ml
[0039] Magnesium Stearate 3mg;
[0040] The preparation method is as follows:
[0041] Pass aceclofenac, HPMC K4M, respectively through a 100-mesh sieve, and mix well. Prepare soft material by wetting with 14% (w / v) PVPK30 alcohol solution, granulate with 16 mesh sieve, dry at 60-80°C, granulate with 20 mesh sieve, mix with magnesium stearate, and tablet.
[0042] The 24-hour cumulative release rate of the product of this embodiment is 71%.
Embodiment 2
[0044] The prescription for each tablet is as follows:
[0045] Aceclofenac 200mg
[0046] Hydroxypropyl Methyl Cellulose (HPMC E4M) 86mg
[0047] 14% (W / V) PVP K-30 alcohol solution 50ml
[0048] Magnesium Stearate 3mg;
[0049] The preparation method is as follows:
[0050] Pass aceclofenac, HPMC E4M, respectively through a 100-mesh sieve, and mix well. Prepare soft material by wetting with 14% (w / v) PVPK30 alcohol solution, granulate with 16 mesh sieve, dry at 60-80°C, granulate with 20 mesh sieve, mix with magnesium stearate, and tablet.
[0051] The 24-hour cumulative release rate of the product of this embodiment is 72%.
Embodiment 3
[0053] The prescription for each tablet is as follows:
[0054] Aceclofenac 200mg
[0055] Hydroxypropyl Methyl Cellulose (HPMC K4M) 86mg
[0056] Carbopol 934 P 3mg
[0057] 14% (W / V) PVP K-30 alcohol solution 50ml
[0058] Magnesium Stearate 3mg;
[0059] The preparation method is as follows:
[0060] Pass aceclofenac, HPMC K4M, and Carbopol 934 P through a 100-mesh sieve, and mix well. Prepare soft material by wetting with 14% (w / v) PVP K30 alcohol solution, granulate with 16 mesh sieve, dry at 60-80°C, granulate with 20 mesh sieve, mix with magnesium stearate, and tablet.
[0061] The 24-hour cumulative release rate of the product of this embodiment is 65%.
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