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High-molecular fucoidan, method of producing the same and cosmetic composition

A technology of fucoidan and low-molecular compounds, which is applied in the field of high-molecular fucoidan, its preparation, and cosmetic compositions, can solve the problems of not prompting fucoidan, etc., and achieve excellent storage stability, Excellent moisturizing effect

Inactive Publication Date: 2008-01-02
UBE IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] However, there is no suggestion to use fucoidan from Cladosiphon sources in cosmetic or dermatological field medicaments
[0019] In this way, fucoidan is expected to be used as an agent in the field of dermatology such as cosmetics or antiallergic effects, but so far in these fields, there has been no use of fucoidan for stickiness, feeling of use, or antiallergic effects. An example of research on the relationship between the function of the product and its weight average molecular weight

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] [14] The high molecular weight fucoidan with a weight-average molecular weight of 1,000,000-2,000,000 obtained by the preparation method of the present invention is used as a cosmetic (lotion, hairdressing, etc.) and a medicament in the field of dermatology (skin cell activator or components of compositions such as allergens) can be appropriately contained.

[0048] Hereinafter, the production method of the high molecular weight fucoidan of the present invention will be described in accordance with the steps.

[0049]

[0050] The extraction operation is carried out on a suspension made by initially suspending the haiyun in tap water or purified water. The use amount of these waters is not particularly limited as long as it is an amount that can effectively extract the kelp, but when using dried kelp, for example, it is preferable to use 50 to 300 g of water per 1 g of the dried kelp.

[0051] [15] Then, at the beginning of extraction, in order to make the above-mentio...

Embodiment 1

[0062] Ethanol was added at a final concentration of 50% by weight to live algae of Tonga-produced sea algae (Cladosiphon novae-caledoniae), and after immersing for 30 minutes for decolorization, the ethanol fraction was removed as much as possible by centrifugal filtration to prepare processed kelp.

[0063] In 1350 ml of water, 150 g of the above-mentioned processed seaweed was added, then 13.2 g of hydrogen peroxide water and 0.84 g of potassium hydroxide with a concentration of 30% by weight were added, and the mixture was stirred at 90-95° C. for 1 hour. After cooling to 50°C, the residue was removed by filtration.

[0064] Since the obtained filtrate had pH=6.3, it was adjusted to pH=7.2 with a 1 mol / L (liter) potassium hydroxide aqueous solution.

[0065] Then, it was concentrated to about 1 / 5 of the volume using an ultrafiltration membrane having a fractional molecular weight of 10,000.

[0066] The obtained aqueous solution was adjusted to pH=6.5 with 1 mol / L (liter)...

Embodiment 2

[0079] Preparation of Ethanol Precipitates of High Molecular Weight Fucoidan

[0080] 100 g of the high molecular weight fucoidan aqueous solution obtained in Example 1 was concentrated to about 1 / 2 volume at 50°C under reduced pressure. The fucoidan was precipitated by adding ethanol in an amount equivalent to 4 times the volume of the concentrate and centrifuged (3000 rpm, 5 minutes, 4°C). Then, the obtained residue was washed twice with ethanol and dried at 50°C under reduced pressure (0.001 MPa) to prepare a high molecular weight fucoidan precipitate (0.876 g).

[0081] Hereinafter, it is referred to as "high molecular weight fucoidan".

[0082] [23] Preparation of an aqueous solution of hydrolyzed fucoidan and its ethanol precipitate

[0083] 100 g of the high molecular weight fucoidan aqueous solution obtained in Example 1 was adjusted to pH=5 with the sulfuric acid specified in 1 hour), an aqueous solution of hydrolyzed fucoidan was obtained.

[0084] These hydroly...

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Abstract

It is intended to provide a method of producing a high-molecular weight fucoidan, which is expected as usable as cosmetics and dermatological drugs, and a composition containing the high-molecular weight fucoidan. A composition containing fucoidan having a weight-average molecular weight of from 1,000,000 to 2,000,000, which is obtained by extracting Cladosiphon okamuranus with hot water under neutral to alkaline conditions of pH 6.0 or higher, removing low-molecular compounds by ultrafiltration and adjusting the final pH value to 6.5 or higher, is efficacious as cosmetics and drugs in the field of dermatology and has an excellent storage stability.

Description

technical field [0001] [01] The present invention relates to a method for preparing high molecular weight fucoidan with a weight average molecular weight of 1,000,000-2,000,000 obtained from seaweed and a fucoidan-containing composition containing the high molecular weight fucoidan, especially Compositions in the dermatological field (cosmetics, skin cell activators and allergens). Background technique [0002] [02] Fucoidan is a type of acidic polysaccharide polymer mainly composed of sulfated fucose, and is a viscous component contained in brown algae such as kelp and kelp. Fucoidan has various pharmacological effects such as anti-tumor, anti-stomach ulcer, anti-virus, anti-inflammatory, anti-blood coagulation, and immunity enhancement. In addition, it is a substance expected to be used in the fields of cosmetics and dermatology because of its moisturizing function, skin cell activation effect, anti-allergic effect, agglutination effect, thickening effect, surface active ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P43/00A61K31/737A61Q5/00A61K8/73A61Q19/00A61P37/08
CPCA61K31/737A61Q19/00C08B37/006A61Q5/00A61K8/73A61P17/00A61P37/08A61P43/00
Inventor 秦野耕司中本泰金築祐
Owner UBE IND LTD
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