Production process of glucosamine lysine selenium salt
A technology of glucosamine hydrochloride and glucosamine is applied in the directions of pharmaceutical formulations, sulfur/selenium/tellurium active ingredients, medical preparations containing active ingredients, etc. The effect of low production cost and easy availability of raw materials
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[0016] A kind of production method of glucosamine lysine selenium salt, comprises the following steps successively:
[0017] (1) Preparation of glucosamine: Glucosamine hydrochloride is used as raw material, and glucosamine is obtained through neutralization reaction of an acid-binding agent. The consumption molar ratio of glucosamine hydrochloride and acid binding agent is: 1: 1.1-1.3 (example 1: 1.1, 1: 1.2, 1: 1.3), temperature is 20-50 ℃ (example 20 ℃, 35 ℃, 50 ℃ ℃), the time is 5-30 minutes (example 5, 15, 30 minutes), and the obtained glucosamine purity reaches more than 99%. Wherein the acid-binding agent is a mixed solution of methanol and sodium methylate, and the weight ratio of methanol and sodium methylate in the acid-binding agent is 3 to 8:1 (eg 3:1, 5:1, 8:1).
[0018] (2) Preparation of glucosamine selenite: using alcohol organic solvent system (or lipid, amide organic solvent system), glucosamine is coordinated and complexed with a certain proportion of selen...
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