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Chinese medicine composition containing red sage, notoginseng and musk or muskone and its prepn

The technology of a composition and musk ketone is applied in the directions of pharmaceutical combinations, medical preparations containing active ingredients, and medical preparations with non-active ingredients, etc. Problems such as low pollution ability and incompletely clear active ingredients

Active Publication Date: 2007-12-19
TIANJIN TASLY PHARMA CO LTD
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AI Technical Summary

Problems solved by technology

[0006] (1) The composition of Chinese herbal medicine is complex, especially in many compound preparations, the active ingredients are not fully clear, so it is necessary to carry out very in-depth research before applying ultrafiltration technology to Chinese herbal medicine preparations
For example, due to the complexity of the ingredients, it is impossible to apply ultrafiltration to the production of most traditional Chinese medicine preparations before a large number of pharmacological and clinical research tests are conducted to fully evaluate the effect of ultrafiltration on the efficacy of each ingredient in traditional Chinese medicine preparations.
[0007] (2) There are few types of membrane materials, the membrane pore size distribution is wide, and the performance is not stable
Hydrophilic membrane materials such as cellulose acetate and sulfonated polysulfone have less adsorption of solutes and a smaller molecular weight cut-off, but poor thermal stability, mechanical strength, chemical resistance, and bacterial erosion resistance are usually not high; polysulfone and other hydrophobic Membrane material has high mechanical strength, high temperature resistance, solvent resistance, and biodegradation resistance, but because the molecular chain contains a large number of hydrophobic genes or chain links, and has a lot of electrostatic charges, the membrane has a low water permeability and low anti-pollution ability
[0008] (3) Membrane fouling is the biggest obstacle preventing ultrafiltration technology from laboratory research to industrial application stage
In the ultrafiltration process of traditional Chinese medicine preparations, if the pretreatment effect of the liquid medicine is not good, the membrane surface will be easily polluted and the membrane pores will be blocked, which will reduce the permeation flux, that is, the productivity, or even fail to work normally, reduce the production efficiency, and increase the cost, resulting in membrane shortened service life
[0009] (4) The selection method of membrane modules has not yet been established, and the operating parameters of ultrafiltration still need to be optimized
However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The raw materials are 450g of Danshen, 76g of Panax notoginseng, and 8g of musk.

[0072] Extracting Danshen with ethanol to obtain an ethanol extract of Danshen, filtering the extract with gauze, and collecting the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m / s. During the ultrafiltration process, periodic flow fluctuations are u...

Embodiment 2

[0075] The raw materials are 558g of Danshen, 34g of Radix Notoginseng and 8g of Moschus.

[0076] The salvia miltiorrhiza and notoginseng are extracted with 70% ethanol to obtain the ethanol extract of the salvia miltiorrhiza and notoginseng, and the ceramic membrane is used for microfiltration to collect the filtrate. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed l...

Embodiment 3

[0078] The raw material medicine adopts salvia miltiorrhiza 500g, notoginseng 94g, musk 8g.

[0079] Put the coarsely crushed Danshen and Panax notoginseng into the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, and discard the filter residue To, combine the filtrates. The filtrate was ultrafiltered with a cellulose triacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuat...

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Abstract

The present invention discloses one kind of Chinese medicine composition for treating cardiac vascular diseases and its preparation process. The Chinese medicine composition is prepared with red sage, notoginseng and musk or muskone as the material medicines. The preparation process includes the following steps: 1. extracting red sage and notoginseng with water or alcohol to obtain extracted solution; 2. clarifying the extracted solution; 3. ultrafiltering the extracted solution; and 4. concentrating the filtrate to obtain extractum, and mixing the extractum with musk or muskone. The Chinese medicine composition may be prepared into different preparations, preferably dripping pill.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular diseases and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases which is made from traditional Chinese medicinal materials. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. Although there are many Chinese pat...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122
Inventor 李旭郑永锋李学敏
Owner TIANJIN TASLY PHARMA CO LTD
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