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Probiotics components with enteric solubility gastric-acide-tolerance coatings

A probiotic, gastric acid-resistant technology, applied in applications, animal feed, animal feed, etc., can solve the problems of incomplete bone calcification, inability to effectively curb the outbreak of infectious diseases, and failure of drug treatment. The effect of improving the viability of bacterial agents

Inactive Publication Date: 2007-11-28
BION TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the past, most of the livestock feed additives used in economical animals were antibiotics. However, as a result of the abuse of antibiotics, pathogenic bacteria were induced to develop drug resistance, which made drug treatment ineffective and could not effectively curb the outbreak of infectious diseases. After consumption, it will have a serious impact on human health, such as tetracycline causing incomplete bone calcification or inability to use first-line antibiotics, causing tuberculosis or infectious diseases to wreak havoc again in recent years

Method used

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  • Probiotics components with enteric solubility gastric-acide-tolerance coatings
  • Probiotics components with enteric solubility gastric-acide-tolerance coatings
  • Probiotics components with enteric solubility gastric-acide-tolerance coatings

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Experimental program
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Effect test

Embodiment 1

[0014] The bacterial liquid of probiotics is mixed with water-soluble and enteric-soluble coating materials and excipients to form a mixed solution, and then the mixed solution is spray-dried simultaneously to obtain a spherical powder, and the coating material will not dissolve in acid. It was spray-dried to detect the number of bacteria. The following table 1 refers to the output value of the microencapsulated biobacteria products made with different coating materials. Among them, the coating rate of the formula EC-0 in table 4 reaches 80-81%, for the preparation of L103 containing endospores, its survival rate reaches 100%, but for the strain (PS551), the survival rate is only 67%, if about 0.5 ECN-7 (ethyl cellulose) is added to the formula %, immediately increase its survival rate (%) to 92%, the more ECN-7 (vinyl cellulose) is added, the higher the survival rate, and the ECN-7 contained in the formula EC-2 can be known from the table below (Ethyl cellulose) reached 2% an...

Embodiment 2

[0018] According to the probiotics described in Experiment 1, the probiotics were coated with coating materials and then spray-dried to obtain powders of the desired shape. The results are shown in Table 2. Through the dissolution test, it was found that PS551 did not have acid resistance after being developed with the formula EC-0, 1, 2, 4, 41 of Experiment 1, although the bacteria would not collapse in acidic liquid after coating, But 0.03N HCL hydrochloric acid can still infiltrate in the microcapsule, PS551 can be killed (survival rate. The viability of 4M was still 99% in 0.01N HCl for 1 hour, and its viability was still 33% in 0.03N HCl for 1 hour.

[0019] Three formulas add 400ml of strains

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Abstract

The intestine soluble gastric acid resistant coated probiotics preparation consists of milk powder 15-20 wt%, corn starch 25-30 wt%, modified starch 8-15 wt%, ethyl cellulose 10-15 wt%, bacterial broth 5-10 wt% and talc powder 10-15 wt%. It is prepared into microcapsule, and has high gastric acid resisting and intestine solubility, high probiotics survival rate, high bacteriostasis property, high stability and less caking, and may be used as feed additive for farm animal.

Description

technical field [0001] The invention relates to a probiotic composition with enteric gastric acid-resistant coating. Background technique [0002] In the past, most of the livestock feed additives used in economical animals were antibiotics. However, as a result of the abuse of antibiotics, pathogenic bacteria were induced to develop drug resistance, which made drug treatment ineffective and could not effectively curb the outbreak of infectious diseases. After consumption, it will have a serious impact on human health, such as incomplete bone calcification caused by tetracycline or inability to use first-line antibiotics, which has caused tuberculosis or infectious diseases to wreak havoc again in recent years. In addition, the cholesterol and triglycerides in pigs can also cause obesity or cardiovascular diseases in consumers. At present, relevant domestic and foreign organizations have begun to review the problem of drug abuse. Therefore, they plan to promote some non-drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A23K10/18
Inventor 陈良荣
Owner BION TECH INC
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