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Ready-for-use injectable solution of 9-((1,3-dihydroxypropan-2-iloxy)methyl)-2-amine-1h-purin-6(9h)-one

A technology of dihydroxy and oxy groups, applied in the field of injection solutions

Inactive Publication Date: 2007-11-14
HALEX ISTAR IND FARM LTDA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, adding other medications by removing the device attached to the bottle poses a higher risk of contamination

Method used

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  • Ready-for-use injectable solution of 9-((1,3-dihydroxypropan-2-iloxy)methyl)-2-amine-1h-purin-6(9h)-one

Examples

Experimental program
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Effect test

Embodiment I

[0056] Preparation of 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino in its basic form -1H-purin-6(9H)-one free acid form without free basic residue method

[0057] Add 15 g of caustic soda to a suspension of 100 g of 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino-1H-purin-6(9H)-one in 1 L of demineralized water, pH 11.5, all dissolved. Thereafter, the temperature of the solution was raised to 85° C., and about 6 g of fuming hydrochloric acid were added until pH=4.5. The solution was cooled to 5 °C and 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino-1H-purin-6(9H)-one (free acid form) crystallized . After stirring at 5°C for 30 minutes, the solid was filtered and washed with isopropanol. Suspend the solid of 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino-1H-purin-6(9H)-one in isopropanol and reflux vigorously for 4 h . The suspension was cooled to room temperature (25°C) and immediately filtered. The resulting 9-((1,3-dihydroxyprop-2-yloxy)methyl)-2-amino-1H-purin...

Embodiment II

[0059] Preparation of 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino in its basic form -1H-purin-6(9H)-one free acid form without free basic residue method

[0060] In a glass reactor equipped with a reflux condenser, 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino-1H-purine-6(9H )-ketone ratio of 10 parts, 9-((1,3-dihydroxyprop-2-yloxy)methyl)-2-amino-1H-purin-6(9H)-one was suspended in demineralized water, Stir vigorously at room temperature until completely homogeneous. Into the resulting suspension under stirring, with respect to 9-((1,3-dihydroxypropan-2-yloxy)methyl)-2-amino-1H-purin-6(9H)-one The equivalent of 1.1 moles of sodium hydroxide is added to sodium hydroxide (caustic soda), and the suspension is completely dissolved. Thereafter, with stirring, the temperature of the solution was raised to 85° C., and fuming hydrochloric acid was added until the pH of the solution was 4.5, using about 5.4 to 6.6 g of hydrochloric acid. In order to crystallize 9-((1,3-di...

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Abstract

To provide a ceramic body for a dielectric resonator with a high no-load Q wherein the dielectric resonator and a support base are strongly tightened and fixed and to provide a manufacturing method thereof and the dielectric. The dielectric resonator use ceramic body comprises: the columnar or cylindrical dielectric resonator made of a dielectric ceramic material; and the support base 14 made of a ceramic material for supporting an end of the dielectric resonator 12. In the dielectric resonator use ceramic body, the end of the dielectric resonator 12 and the end of the support base 14 are tightened and fixed by fitting and the dielectric ceramic material of the dielectric resonator 12 and the ceramic material of the support base 14 are diffused in borders 30 between the dielectric 12 and the support base 14.

Description

technical field [0001] The present invention describes a sterile, stable and ready-to-use injectable solution comprising 9-((1,3-dihydroxypropan-2-yloxy)methyl in 5% dextrose in water or 0.9% sodium chloride in water )-2-amino-1H-purin-6(9H)-one. A closed system for packaging the solution is also described, consisting of a flexible bag made of three layers of material. The invention also describes the elimination of basic residues present in 9-((1,3-dihydroxypropan-2-yloxy)-methyl)-2-amino-1H-purin-6(9H)-one process, thus obtaining crystals free of alkaline residues and suitable for direct preparation of solutions. Background technique [0002] Propoxyguanidine (9-((1,3-dihydroxy-2-propoxy)methyl)guanine or DHPG, or 2-amino-1,9-((2-hydroxy-1-(hydroxymethyl) Base) ethoxy) methyl-6-H-purin-6-one, or 9-((1,3-dihydroxyprop-2-yloxy)methyl)-2-amino-1H-purine- 6(9H)-keto) is a synthetic drug derived from acyclovir, as described in patent US4,355,032, shown to be active against ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/52B32B27/32B32B27/36A61J1/00A61KA61P31/12C07D473/00
CPCB32B27/32A61K31/52A61P31/12A61P31/20A61P31/22B32B27/08B32B27/36B32B2307/7246B32B2323/04B32B2307/306B32B2307/554
Inventor H·佩里洛J·坎波斯内托M·克鲁切利
Owner HALEX ISTAR IND FARM LTDA
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