HCV composite multi-epitope transgene plant oral vaccine

Abstract

This invention is one kind of hepatitis C virus (HCV) compound multi-epi-position transgene edibility plant vaccine. States the HCV vaccine is the HCV compound multi-epi-position antigen gene, in the plant expresses in the host-based system to express obtains, and states the plant expresses the host is edibility. This invention provided one kind highly effective moderately-priced in view of the same type, different HCV separation not to be able to provide the overlapping protective function the effective HCV vaccine.

Description

1. Technical field [0001] The invention belongs to the field of molecular biology and relates to an edible transgenic vaccine prepared by using plants, in particular to a transgenic edible vaccine for preventing human hepatitis C virus infection; the amino acid sequence of the recombinant protein; encoding the recombinant protein The nucleotide sequence of the vaccine (hereinafter sometimes referred to as "gene"); the expression vector containing the nucleotide sequence; the host cell containing the expression vector. 2. Background technology [0002] Hepatitis C is an infectious disease that seriously affects human health. It can easily transform into liver cirrhosis and hepatocellular carcinoma. At present, there is no ideal prevention and treatment method. It is one of the important sources of disease that endangers human health. There are about 170 million HCV infected people in the world, and it is estimated that my country accounts for more than 40 million. Therefore, ...

AI Technical Summary

Problems solved by technology

Although their expression system is an edible plant, they did not use a compound polyepitope gene, which reduces the immunity of the product

[0010] At present, there is no expression of HCV compound multi-epitope antigen gene in edible plants