Riemerella anatipestifer tervalent inactivated vaccine and preparation method thereof

Abstract

The invention belongs to the field of biotechnology, and discloses a riemerella anatipestifer tervalent inactivated vaccine. The inactivated vaccine comprises a riemerella anatipestifer serotype I inactivated whole bacterium, a serotype II inactivated whole bacterium, a serotype X inactivated whole bacterium and an adjuvant. The immune protection ratio of the inactivated vaccine against the toxicity attack from the serotype I, II and X type riemerella anatipestifer virulent strains reaches up to 100%. The inactivated vaccine provided by the invention has a good immune protection effect on all serotype strain infections.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular, the invention relates to a trivalent inactivated vaccine of Riemerella anatipestifer and a preparation method thereof. Background technique [0002] Riemerella anatipestifer (RA) infection is a highly pathogenic and contagious disease of ducks, geese, turkeys and other birds. The disease is more common in ducklings aged 10-35 days, the highest incidence rate can reach more than 90%, and the mortality rate is 5%-75%. It is one of the major infectious diseases affecting the duck industry. [0003] There are many RA serotypes, 21 of which have been identified in the world at present, and the cross-protection effect between each serotype is poor. Studies have shown that the dominant serotypes of RA infection epidemic strains in my country are 1, 2 and 10. At present, the vaccine that can be used to prevent RA infection in China is duck infectious serositis inactivated oil emulsion vaccine...

AI Technical Summary

Problems solved by technology

Studies have shown that the dominant serotypes of RA infection epidemic strains in my country are 1, 2 and 10. At present, the vaccine that can be used to prevent RA infection in China is duck infectious serositis inactivated oil emulsion vaccine. Vaccines for R. anatipestifer infection have no protective effect against serotype 2 and 10 R. anatipestifer infections that frequently occur in China

Due to the limitation of bacterial culture medium and other factors, it is difficult to cultivate the number of bacteria required for the preparation of trivalent inactivated vaccines. So far, there is no RA including serotypes 1, 2 and 10 of Riemerella anatipestifer. Research reports on trivalent inactivated vaccines or commercialized vaccines

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