Riemerella anatipestifer trivalent inactivated vaccine and preparation method thereof

A technology of Riemerella anatipestiferus and inactivated vaccines, which is applied in the field of trivalent inactivated vaccines of Riemerella anatipestifer and its preparation, can solve the problem of no preventive protection, no research reports, and difficulty in reaching the trivalent number of bacteria Requirements for the number of bacteria in inactivated vaccines and other issues

Active Publication Date: 2016-01-06
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that the dominant serotypes of RA infection epidemic strains in my country are 1, 2 and 10. At present, the vaccine that can be used to prevent RA infection in China is duck infectious serositis inactivated oil emulsion vaccine. Vaccines for R. anatipestifer infection have no protective effect against serotype 2 and 10 R. anatipestifer infections that frequently occur in China
Due to the limitation of bacterial culture medium and other factors, it is difficult to cultivate the number of bacteria required for the preparation of trivalent inactivated vaccines. So far, there is no RA including serotypes 1, 2 and 10 of Riemerella anatipestifer. Research reports on trivalent inactivated vaccines or commercialized vaccines

Method used

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  • Riemerella anatipestifer trivalent inactivated vaccine and preparation method thereof
  • Riemerella anatipestifer trivalent inactivated vaccine and preparation method thereof
  • Riemerella anatipestifer trivalent inactivated vaccine and preparation method thereof

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[0026] Below in conjunction with specific embodiment, further illustrate the present invention. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art.

[0027] The reagents and raw materials not marked in the present invention are purchased from the market.

[0028] 1: Rejuvenation and identification of candidate strains for seedling production

[0029] Our previous research obtained candidate strains CH3, NJ3 and HXb2 for serotype 1, 2 and 10 vaccine production. The morphology, biochemical reaction characteristics, molecular biological characteristics and immune protect...

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Abstract

The invention belongs to the field of biological technology, and the invention discloses a trivalent inactivated vaccine of Riemerella anatipestifer, which contains an inactivated Riemerella anatipestifer serotype 1 Whole bacteria, serotype 2 inactivated whole bacteria and serotype 10 inactivated whole bacteria and adjuvant. The immune protection rate of the invention against serotype 1, 2 and 10 Riemerella anatipestifer virulent strains all reaches 100%. The invention has a good immune protection effect on the infection of various serotype bacterial strains.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular, the invention relates to a trivalent inactivated vaccine of Riemerella anatipestifer and a preparation method thereof. Background technique [0002] Riemerella anatipestifer (RA) infection is a highly pathogenic and contagious disease of ducks, geese, turkeys and other birds. The disease is more common in ducklings aged 10-35 days, the highest incidence rate can reach more than 90%, and the mortality rate is 5%-75%. It is one of the major infectious diseases affecting the duck industry. [0003] There are many RA serotypes, 21 of which have been identified in the world, and the cross-protective effect between each serotype is poor. Studies have shown that the dominant serotypes of RA infection epidemic strains in my country are 1, 2 and 10. At present, the vaccine that can be used to prevent RA infection in China is duck infectious serositis inactivated oil emulsion vaccine. Vaccines ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/116A61P31/04C12N1/20
Inventor 于圣青丁铲韩先干王小兰仇旭升宋翠萍谭磊
Owner SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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