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Method of synthesizing monodisperse micron-level poly(methyl methacrylate) micro-sphere

A technology of polymethyl methacrylate and methyl methacrylate, which is applied in the field of preparation of functional polymer materials, can solve problems such as poor repeatability of the method, poor affinity of polar molecules, and the uniformity of microspheres that cannot meet practical requirements.

Active Publication Date: 2007-10-17
北京鼎国昌盛生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, polystyrene microspheres are subject to many limitations in application. For example, when used as a functional material, due to its non-polar characteristics, it has poor affinity for polar molecules, and it is still necessary to introduce functional groups to expand its application range.
Polymethyl methacrylate microspheres are moderately polar particles that swell faster as seeds in swelling than polystyrene as seeds; polymethyl methacrylate microspheres can either be used directly or further derivatized It is also much easier to synthesize than polystyrene. It has been reported in the literature that polymethyl methacrylate microspheres with uniform size have been synthesized. However, it has been found that the published methods have poor repeatability and the uniformity of the microspheres cannot be achieved. Practical requirements, there is an urgent need for simple, stable and reliable preparation methods

Method used

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  • Method of synthesizing monodisperse micron-level poly(methyl methacrylate) micro-sphere
  • Method of synthesizing monodisperse micron-level poly(methyl methacrylate) micro-sphere

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: Dissolve 1.5g of PVPK-30 in 25.0g of methanol, transfer to a 100ml glass container, then add 2.5g of MMA containing 75mgAIBN, pass N 2 10 minutes, put into stirring bar then, seal container opening, be placed on the magnetic stirrer with the speed of 60rpm and stir evenly, maintain this rotating speed in the whole reaction process. The temperature was raised at a rate of 12.5°C / hour, finally stabilized at 50°C, and reacted for 18 hours. After the reaction was completed, it was centrifuged / redispersed and washed 4 times with methanol, and vacuum-dried at room temperature. The average particle size is 3.67 μm, and the product number particle size distribution CV is 3.21%.

Embodiment 2

[0029] Embodiment 2: the PVP K-30 of 0.5g is dissolved in the ethanol of 25.0g, transfers in the glass container of 100ml, adds in the MMA of 2.5g containing 150mg AIBN again, passes N 2 10 minutes, put into stirring bar then, seal container opening, be placed on the magnetic stirrer with the speed of 60rpm and stir evenly, maintain this rotating speed in the whole reaction process. The temperature was raised at a rate of 5°C / hour, and finally stabilized at 40°C, and reacted for 18 hours. After the reaction was completed, it was centrifuged / redispersed and washed 4 times with methanol, and vacuum-dried at room temperature. The average particle size is 2.83 μm, and the product number particle size distribution CV is 4.37%.

Embodiment 3

[0030] Example 3: Dissolve 1.5g of PVPK-30 in 25.0g of methanol, transfer to a 100ml glass container, then add 2.5g of MMA containing 12.5mgAIBN, pass N 2 10 minutes, put into stirring bar then, seal container opening, be placed on the magnetic stirrer with the speed of 60rpm and stir evenly, maintain this rotating speed in the whole reaction process. The temperature was raised at a rate of 10°C / hour, finally stabilized at 55°C, and reacted for 18 hours. After the reaction was completed, it was centrifuged / redispersed and washed 4 times with methanol, and vacuum-dried at room temperature. The average particle size is 4.01 μm, and the product number particle size distribution CV is 2.88%.

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Abstract

The invention discloses a method for producing monodisperse micron polymethyl methacrylate with a method for controlling temperature raising speed in the initial phase of the polymethyl methacrylate dispersive polymerization. The monodispersion of the polymethyl methacrylate micrballon produced by disclosed polymethyl methacrylate dispersive polymerization agent can not meet the requirement and has a bad repeatability. The invention strictly controls the temperature raising speed, which is less than 12.5 DEG C / hour, and more than 5 DEG C / hour. Thus, the produced micrballon has a similar grain diameter with an average value between 2.5 mum to 8 mum, a grain diameter distribution coefficient between 0.01 to 0.05. The dispersed polymethyl methacrylate micrballon can be widely applied in the biomedicine field such as clinic diagnosis, immunity technology, cytology.

Description

technical field [0001] The invention relates to a method for preparing monodisperse micron-sized polymethyl methacrylate microspheres, in particular to a method for preparing polymethyl methacrylate microspheres with uniform particle size by controlling the heating rate and utilizing dispersion polymerization technology. The method belongs to the field of preparation of functional polymer materials. Background technique [0002] In recent years, synthetic polymer microspheres have attracted people's attention, and advanced research institutions and large commercial companies have increased their investment in theoretical research and application development of synthetic polymer microspheres. There are more and more applications in the fields of coatings, chemistry, biology, biomedicine, and sustained drug release. Synthetic polymer microspheres show bright prospects, especially in the fields of biotechnology and medical engineering. [0003] From the perspective of the diam...

Claims

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Application Information

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IPC IPC(8): C08F120/14C08F2/44C08F2/12
Inventor 张丛云周卫东
Owner 北京鼎国昌盛生物技术有限责任公司
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