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Preparation method and application for phyllanthus oral solid preparations

A solid preparation and preparation technology, which is applied in the field of preparation of oral solid preparations of Phyllostachys phylloxera, can solve problems affecting the pharmacological effects of active ingredients of Phyllostachys phylloxera, removal of impurities from solutions, and affecting the therapeutic effect of hepatitis B, so as to achieve good anti-hepatitis B virus , little environmental pollution and low cost

Active Publication Date: 2007-10-17
广东鼎信医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This application uses water or an organic solvent as a solvent to extract the active ingredients in Phyllanthus phylloxera. This method is simple, but water extraction will simultaneously extract a large amount of macromolecular substances such as proteins, tannins, and organic pigments. The removal of impurities in the solution has seriously affected the pharmacological effects of the active ingredients of Phyllostachys phylloxera
The application number is 200410039386.5 in the patent application using alcohol or acetone as the extraction solvent to extract polyphenolic compounds from Phyllanthus phylloxera. The other active ingredients of Phyllostachys phylloxera have not been elaborated, which has seriously affected the therapeutic effect of Phyllanthus phylloxera in treating hepatitis B

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] 1. Preparation of main drug

[0071] (1) Take 500g of Phyllostachys phylloxera medicinal material and pulverize it, extract once with n-hexane reflux for 2 hours, combine the extracts, recover the solvent under reduced pressure, and obtain the effective part A;

[0072] (2) evaporate the solvent from the dregs extracted by n-hexane, and extract once with 50% ethanol under reflux for an extraction time of 1 hour, combine the extracts, recover ethanol under reduced pressure, and obtain extract I;

[0073] (3) evaporate the solvent from the dregs after ethanol extraction, reflux extraction with water once, each time for 1 hour, combine the extracts, concentrate to a thick paste with a relative density of 1.1, and obtain the extract II;

[0074] (4) Combine the extracts I and II, put them on a D101 macroporous adsorption resin column, elute with 40% ethanol, combine the eluents, recover the ethanol under reduced pressure, and obtain the effective part B;

[0075] The effec...

Embodiment 2

[0085] 1. Preparation of main drug

[0086] (1) Take 1200g of Phyllostachys phylloxera medicinal material and pulverize it, extract it twice with n-hexane reflux, each time for 3 hours, combine the extracts, recover the solvent under reduced pressure, and obtain the effective part A;

[0087] (2) volatilize the dregs after n-hexane extraction to dry the solvent, and extract twice with 55% ethanol under reflux, each time for 1.5 hours, combine the extracts, recover the ethanol under reduced pressure, and obtain the extract I;

[0088] (3) The dregs after ethanol extraction were evaporated to dry solvent, extracted with water for 2 times under reflux, each time for 1.5 hours, and the extracts were combined and concentrated to a thick paste with a relative density of 1.2 to obtain the extract II;

[0089] (4) Combine the extracts I and II, put them on the HP20 macroporous adsorption resin column, elute with 45% ethanol, combine the eluents, recover the ethanol under reduced press...

Embodiment 3

[0100] 1. Preparation of main drug

[0101] (1) Take 1500g of Phyllostachys phylloxera medicinal material and pulverize it, extract it with n-hexane reflux for 3 times, each time for 4 hours, combine the extracts, recover the solvent under reduced pressure, and obtain the effective part A;

[0102] (2) volatilize the dregs after n-hexane extraction to dry the solvent, reflux extraction with 60% ethanol for 3 times, each time for 2 hours, combine the extracts, recover the ethanol under reduced pressure, and obtain the extract I;

[0103] (3) The dregs after ethanol extraction were evaporated to dry solvent, extracted twice with water under reflux, each time for 2 hours, and the extracts were combined and concentrated to a thick paste with a relative density of 1.3 to obtain the extract II;

[0104] (4) Combine the extracts I and II and put them on LD 605 A macroporous adsorption resin column, eluting with 55% ethanol, combining the eluents, recovering ethanol under reduced pre...

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PUM

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Abstract

The invention discloses a preparing method for common leafflower herb oral solid preparation and its application. The effective components of the common leafflower herb are extracted by three solvent with different polarity of n-hexane, ethanol and water. Then the main medicine is obtained by refining respective extracting parts and combinating obtained effective part group. The invention adds some proper medical accessory to produce the common leafflower herb oral solid preparation which has a stronger antivirus function and repairing liver injury function. The invention fully extracts the effective components of the common leafflower herb, has a low cost and low pollution and is suitable for industry production. Pharmacological experiments prove the inventive common leafflower herb oral solid preparation has a good hepatitis B virus resistance function.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method and application of an oral solid preparation of Phyllostachys phylloxera. Background technique [0002] Phyllanthus urinaria is the dry whole plant of Phyllanthus urinaria L. in the Euphorbiaceae family. It is cool in nature and slightly bitter. It is mainly used in the treatment of infectious hepatitis, enteritis, dysentery, nephritis edema, malnutrition in children, etc. Studies have shown that Phyllostachys chinensis contains flavonoids, lignans, terpenes, tannins, alkaloids and other compounds. Phyllostachys phylloxera has strong anti-hepatitis B virus and liver protection activity, but there are different opinions on the research on the specific anti-hepatitis B virus active ingredients in Phyllostachys pratense. Or the pharmaceutical composition of the extract of Phyllostachys phylloxera for the treatment of h...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61K9/16A61K9/20A61K9/48A61P1/14A61P31/20
Inventor 张树祥阚迎昕崔娜娜
Owner 广东鼎信医药科技有限公司
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