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Chitosan biguanide hydrochloride, preparation method and use thereof

A technology of chitosan hydrochloride and biguanide hydrochloride, applied in the field of chemical biology of renewable resources, to achieve broad-spectrum antibacterial activity, wide antibacterial range, and rich sources of raw materials

Inactive Publication Date: 2010-05-19
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, derivatives such as chitosan biguanide hydrochloride have not yet appeared, and chitosan biguanide hydrochloride is a biologically active guanidine compound, which is used as an agricultural fungicide, disinfectant or as an industrial antimicrobial agent. etc., are of great economic significance

Method used

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  • Chitosan biguanide hydrochloride, preparation method and use thereof
  • Chitosan biguanide hydrochloride, preparation method and use thereof
  • Chitosan biguanide hydrochloride, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: take by weighing 1.0g molecular weight between 1.0-300,000, deacetylation degree is 80-97% chitosan, add 20mL concentration and be the hydrochloric acid solution of 0.2-0.5mol / L, stir until completely dissolving, use Anhydrous ethanol precipitation, the precipitated solid was washed 2-3 times with ethanol, sucked dry, and vacuum-dried to obtain chitosan hydrochloride powder. Add water to the chitosan hydrochloride powder until it dissolves into a solution, add the guanidinating agent-dicyandiamide, which is 1 times the molar mass of the amino group, into the solution, and then stir at 100-120°C until the reaction is complete. After cooling, filter under reduced pressure, precipitate the filtrate with absolute ethanol, wash the filter cake 3 times with absolute ethanol after suction filtration, and dry in vacuum to obtain chitosan biguanide hydrochloride powder. Dissolve the obtained chitosan biguanide hydrochloride powder in water to prepare a solution wit...

Embodiment 2

[0014] Embodiment 2: Take 2.0g by weighing 2.0g degree of deacetylation is 80-97%, molecular weight is 0.5-15×10 4 Chitosan, add 50mL of hydrochloric acid solution with a concentration of 0.2-0.5mol / L, stir until completely dissolved, precipitate with absolute ethanol, wash the precipitated solid with ethanol for 3 times, drain, and dry in vacuum to obtain chitosan salt salt powder. Add water to the chitosan hydrochloride powder until it dissolves into a solution, add the guanidinating agent-dicyandiamide, which is 5 times the molar mass of the amino group, into the solution, and then stir at 100-120°C until the reaction is complete. After cooling, filter under reduced pressure, precipitate the filtrate with absolute ethanol, wash the filter cake twice with absolute ethanol after suction filtration, and dry in vacuum to obtain chitosan biguanide hydrochloride powder. The prepared chitosan biguanide The biguanide group forming the chitosan biguanide hydrochloride in the hydroc...

Embodiment 3

[0015] Embodiment 3: take by weighing 1.0g chitosan, add 30mL concentration and be the hydrochloric acid solution of 0.2-0.5mol / L, stir until dissolving, precipitate with absolute ethanol, the solid that separates out is washed with ethanol, drained, vacuum-dried, obtains Chitosan hydrochloride powder. Add water to the chitosan hydrochloride powder until it dissolves into a solution, add the guanidinating agent-dicyandiamide, which is 5 times the molar mass of the amino group, into the solution, and then stir at 100-120°C until the reaction is complete. After cooling, filter under reduced pressure, precipitate the filtrate with absolute ethanol, wash the filter cake with absolute ethanol after suction filtration, and dry in vacuum to obtain chitosan biguanide hydrochloride powder. The repeating unit of chitosan biguanide hydrochloride is 2-biguanide glucose hydrochloride, its structural formula is:

[0016]

[0017] In the prepared chitosan biguanide hydrochloride, the big...

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Abstract

The invention provides a new chitosan derivate-chitosan biguanide muriate, its preparation and usage, in which, the repeat unit is 2-biguanide glucose muriate, the substitution degree of guanidine is15-50%, and the molecular weight is 0.5-25 ten thousand. This invention uses the reaction of chitosan and dicyandiamide to prepare chitosan biguanide muriate, and has advantages of mild reaction conditions and fewer side effects. The product has good antibacterial activity and water solubility, and can be widely used in medicine, textile industry, agriculture and other fields.

Description

technical field [0001] The invention relates to a novel chitosan derivative synthesized by utilizing natural renewable resource chitosan—chitosan biguanide hydrochloride and its preparation method and use, belonging to the field of renewable resource chemical biology. Background technique [0002] Chitin is a natural polysaccharide extracted from the shells of crustaceans such as shrimps and crabs and the cell walls of fungi. It is also the second largest biomass resource in nature after cellulose. Chitosan is a deacetylated derivative of chitin, which has good biocompatibility, biodegradability, natural non-toxicity and various biological activities, especially antibacterial properties. In recent years, chitosan has been used as a natural Antimicrobial agents have received widespread attention, but chitosan's antibacterial activity is low compared with traditional antibacterial agents, which is not enough to be widely used in food, medicine, and textile industries. And chi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A01N47/44A01P1/00
Inventor 杜予民胡瑛
Owner WUHAN UNIV
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