Compound prepn of artemisinin derivative and histamine H2 receptor agonist

Abstract

The present invention relates to medicine preparation, and is especially medicine composition of artemisinin derivative and histamine H2 receptor agonist. The medicine composition consists of dihydro artemisinin and cimetidine in the weight ratio of 1 to (1-30); dihydro artemisinin and ranitidine in the weight ratio of 1 to (1-25); artemether or other artemisinin derivative and cimetidine in the weight ratio of 1 to (1.5-20); or artemether or other artemisinin derivative and ranitidine in the weight ratio of 1 to (1.5-15). The medicine composition may be prepared into tablet, capsule, suppository, oral liquid or injection. The present invention has reduced artemisinin derivative consumption, raised blood medicine concentration, low cost and other advantages.

Description

Technical field [0001] The invention belongs to pharmaceutical preparations containing organic active ingredients, in particular to artemisinin compound medicine preparations. Background technique [0002] Artemisinin is an antimalarial active ingredient extracted from Artemisia annua of Compositae. Its derivatives include artemether, artether, artesunate and dihydroartemisinin. It is metabolized quickly in the body. T1 / 2 is very short, for example: artesunate for injection, the plasma concentration drops quickly after intravenous injection, T1 / 2 is about 30 minutes; plasma T1 / 2 of dihydroartemisinin tablets is 1.57 hours; artesunate Ester tablet plasma T1 / 2 is about 30 minutes. Due to the rapid metabolism and excretion, artemisinin antimalarial drugs alone in the treatment of falciparum malaria have a short effective blood concentration maintenance time, which is not conducive to the complete killing of malaria parasites, resulting in a high recurrence rate of the disease...

AI Technical Summary

Problems solved by technology

(Journal of Kunming Medical College 2006 (6) 43-46) The extremely large dosage in this article is beneficial to observe the results of animal tissue experiments, while the therapeutic dose of artesunate injection suitable for human body is only 1.2mg / kg-1.5mg / kg kg, and the experiment only involved the compatibility experiment of two single prescriptions of cimetidine and artesunate, no drug compound prescription was proposed, and no other drugs were applied