Prepn process and application in medicine for treating liver fibrosis of curcumin

An anti-hepatic fibrosis and curcumin technology, which is applied in drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of unreliable curative effect, poor reproducibility, complexity, etc., and achieve less adverse reactions, excellent prevention and treatment, resource rich effect

Inactive Publication Date: 2007-08-22
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

TCM anti-hepatic fibrosis undoubtedly shows certain potential value and advantages, but due to the complexity of the origin and composition of crude drugs, the curative effect is not reliable and the reproducibility is poor

Method used

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  • Prepn process and application in medicine for treating liver fibrosis of curcumin
  • Prepn process and application in medicine for treating liver fibrosis of curcumin
  • Prepn process and application in medicine for treating liver fibrosis of curcumin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: common tablet

[0034] Curcumin 400mg

[0035]Mix 1000 times the prescription amount of curcumin and 500g of medical starch to make soft materials and wet granules, dry at 80-100 degrees for 4 hours, add 50g of magnesium stearate after cooling, mix with 50g of pregelatinized starch, and granulate, Tablet pressing, film-coating, and packaging to obtain 1000 tablets.

Embodiment 2

[0036] Embodiment 2: common capsule

[0037] Curcumin 400mg

[0038] Mix 1000 times the prescription amount of curcumin and 500g of medical starch to make soft materials and wet granules, dry at 80-100 degrees for 4 hours, add 50g of magnesium stearate after cooling, mix with 50g of pregelatinized starch, and granulate, Capsules are packed and packaged to obtain 1000 capsules.

Embodiment 3

[0039] Embodiment 3: oral liquid

[0040] Curcumin 400mg

[0041] Mix 1000 times the prescription amount of curcumin and 200g sucrose, add co-solvent, preservative and water to 10000ml, mix well, fill into 10ml glass ampoule, sterilize and pack. Get 1000 bottles of oral liquid.

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PUM

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Abstract

The present invention relates to preparation process and application in medicine for treating liver fibrosis of curcumin. The medicine treating liver fibrosis has curcumin as main effective component and pharmaceutically acceptable carrier, such as excipient, additive and flavoring agent, and may be prepared into different forms, including medicine powder, tablet, micro pill, etc. Curcumin has obvious effect of treating liver fibrosis, no obvious toxic side effect and rich resource.

Description

technical field [0001] The invention relates to the application of curcumin in medicine, in particular to the application of curcumin and its preparation in anti-hepatic fibrosis medicine. Background technique [0002] Liver fibrosis is a common pathological feature of most chronic liver diseases, and it is also an important intermediate link in the further development and deterioration of chronic hepatitis and cirrhosis. Mainly under the action of various injury factors, hepatic stellate cells activate, proliferate, synthesize and secrete a large amount of extracellular matrix, degrade, reduce and deposit more, and form liver fibrosis. There are many causes of hepatic fibrosis. Abroad, especially in European and American countries, alcoholism accounts for the majority (about 50% to 80%). In my country, the main cause of hepatic fibrosis is infection with hepatitis virus. Among HBV-infected patients, 10% to 15% of patients can develop chronic HBV infection, and 25% to 40% o...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K9/08A61K9/10A61K9/16A61K9/28A61K9/48A61P1/16
Inventor 肖健傅红兴李校堃姚崇舜徐恒武
Owner WENZHOU MEDICAL UNIV
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