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Anti-inflammatory and sterilizing preparation

An anti-inflammatory, sterilizing and preparation technology, applied in the field of pharmaceutical preparations, to achieve the effects of low production cost, suitable for storage and transportation, and stable products

Inactive Publication Date: 2007-07-25
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazine[3,2-a]quinoline-3- Eye drops of carboxylic acids and their hydrochlorides and methanesulfonates

Method used

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  • Anti-inflammatory and sterilizing preparation
  • Anti-inflammatory and sterilizing preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Prescription: 3g of compound II, 5.5ml of acetic acid, appropriate amount of 5% sodium hydroxide, 0.9g of sodium chloride, 0.3g of methylparaben and 0.1g of propylparaben, add appropriate amount of water for injection to make eye drops 1000ml, The specification of eye drops is 3mg / ml.

[0061] Preparation: at 10-15°C, add 3g of compound II to 400ml of water for injection, add 5.5ml of acetic acid, stir for 60 minutes, add 5% sodium hydroxide solution to adjust the pH of the solution to 6.2, then add 0.9g of sodium chloride, and stir until Dissolve; in addition, take 0.3g of methylparaben and 0.1g of propylparaben, add 200ml of boiling distilled water to dissolve them; mix the above two solutions, add distilled water to a total of 1000ml, stir well, and use 0.22μ micro Filter through a pore filter, fill, seal tightly, sterilize at 100°C for 30 minutes with circulating steam, and pack in separate packages. Note: Compound II was supplied by a Beijing Chemical Technology C...

Embodiment 2

[0063] Prescription: 4g compound II, 7.5ml acetic acid, appropriate amount of 5% sodium hydroxide, 0.9g sodium chloride, 0.3g methylparaben and 0.1g propylparaben, add appropriate amount of water for injection to make eye drops 1000ml, The specification of eye drops is 4mg / ml.

[0064] Preparation: at 10-15°C, add Compound II to 700ml of water for injection, add 7.5ml of acetic acid, stir for 60 minutes, add 5% sodium hydroxide solution to adjust the pH of the solution to 6.5, then add 0.9g of sodium chloride, and stir until dissolved ;In addition, take 0.3g of methylparaben and 0.1g of propylparaben, add 200ml of boiling distilled water to dissolve them; mix the above two solutions, add distilled water to a total of 1000ml, stir well, and use a 0.22μ microporous Membrane filtration, filling, sealing tightly, sterilizing at 100°C for 30 minutes with flowing steam, subpackaging, ready to use.

Embodiment 3

[0066] Prescription: Compound II hydrochloride 2.21g, acetic acid 1.0ml, appropriate amount of 5% sodium hydroxide, sodium chloride 0.9g, methylparaben 0.3g and propylparaben 0.1g, add appropriate amount of water for injection to prepare Eye drops 1000ml, the specification of eye drops is 2.2mg / ml.

[0067] Preparation: at 10-15°C, add the hydrochloride of Compound II (prepared according to Example 7) to 500ml of water for injection, add 1.0ml of acetic acid, stir for 30 minutes, add 5% sodium hydroxide solution to adjust the pH of the solution to 5.8, Then add 0.9g of sodium chloride and stir until dissolved; in addition, take 0.3g of methylparaben and 0.1g of propylparaben, add 200ml of boiling distilled water to dissolve them; mix the above two solutions, add distilled water to the total Make 1000ml, stir well, filter with 0.22μ microporous membrane, fill, seal tightly, sterilize at 100°C for 30 minutes with circulating steam, and pack separately to get ready.

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Abstract

An eyedrops of the quinolone medicine for treating bacterial conjunctivitis, keratitis, corneal ulcer, dacryocystitis, trachoma, and the eye infection after operation is prepared from the medicine A and additives. Said medicine A is 6-fluoro- 1-methyl, 4-oxy-7-(1-piperazinyl)-4H-[1, 3] thiazine [3, 2-a] quinoline-3- carboxylate, or its hydrochloride, or its methanesulfonate.

Description

technical field [0001] The invention relates to pharmaceutical preparations containing organic active ingredients, in particular to eye drops containing anti-infective quinolones and its use. Background technique [0002] Eye inflammation is mainly caused by infection of the family - Websterella, Diplococcus pneumoniae, Influenza, Streptococcus and Staphylococcus aureus, causing conjunctivitis, usually symptoms are conjunctival hyperemia, increased secretions, or bacterial corneal infection Ulcers, the main clinical symptoms are pain, lacrimation and hyperemia. Brought a lot of misery to the patient, if untimely treatment may cause the danger of vision loss or even blindness. At present, commonly used drugs for ophthalmic inflammation are the second-generation quinolone drugs ofloxacin eye drops, ciprofloxacin eye drops, and levofloxacin eye drops. Due to the widespread use and abuse of these antibiotics, the continuous emergence of bacterial resis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/08A61P27/02A61P31/04
Inventor 刘学斌刘丹青万平黄翔陈矛叶放梁少娟陈绍奎
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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