Sodium alginate/polyethylene glycol blending drug-loading fibre and preparation method and usage thereof

A technology of polyethylene glycol and sodium alginate, which is applied in the fields of alginate artificial filament, wet spinning method, medical science, etc., can solve the problems of high economic cost, elasticity, and insufficient strength, etc., and achieve wide application prospects , excellent mechanical properties, and the effect of improving performance

Inactive Publication Date: 2009-10-28
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sodium alginate fiber has strong water absorption, and the elasticity and strength after fiber formation are not ideal, and its economic cost is also relatively high.

Method used

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  • Sodium alginate/polyethylene glycol blending drug-loading fibre and preparation method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: get 45g viscosity-average molecular weight and be 2.0 * 10 6 Sodium alginate was dissolved in 900ml of distilled water to obtain sodium alginate solution; 2g of polyethylene glycol with a viscosity average molecular weight of 6000 was dissolved in 40ml of distilled water to obtain polyethylene glycol solution. The above two solutions are fully mixed with 4g salicylic acid, filtered, and after degassing under reduced pressure, with 5% to 10% (mass ratio) of CaCl 2 The mixed solution of aqueous solution and absolute ethanol in the ratio of 4:6 to 6:4 is the coagulation solution, and the sodium alginate / polyethylene glycol drug-loaded fiber is prepared by solution spinning at room temperature, and the fiber stretch rate is 20%. Its mechanical properties, water retention value and release performance are listed in Table 1.

Embodiment 2

[0011] Example 2: Dissolve 45g of sodium alginate in 900ml of distilled water to obtain a sodium alginate solution; dissolve 4g of polyethylene glycol in 80ml of distilled water to obtain a polyethylene glycol solution. The above two solutions are fully mixed with 4g salicylic acid, filtered, and after degassing under reduced pressure, with 5% to 10% (mass ratio) of CaCl 2 The aqueous solution and absolute ethanol are mixed in a ratio of 4:6 to 6:4 to form a coagulation liquid, and the sodium alginate / polyethylene glycol drug-loaded fiber is prepared at room temperature through a solution spinning method, and the stretching rate of the fiber is 20%. Its mechanical properties, water retention value and release performance are listed in Table 1.

Embodiment 3

[0012] Example 3: 45g of sodium alginate was dissolved in 900ml of distilled water to obtain a sodium alginate solution; 8g of polyethylene glycol was dissolved in 160ml of distilled water to obtain a polyethylene glycol solution. The above two solutions and 4g salicylic acid were fully mixed, filtered, and after degassing under reduced pressure, at room temperature with 5% to 10% (mass ratio) of CaCl 2 The mixed solution of aqueous solution and absolute ethanol in the ratio of 4:6 to 6:4 is the coagulation solution and the sodium alginate / polyethylene glycol drug-loaded fiber is prepared by the solution spinning method, and the stretching ratio of the fiber is 20%. Its mechanical properties, water retention value and release performance are listed in Table 1.

[0013] The solution spinning method used in the above examples is a prior art, which has been described in detail in the patent No. ZL200510018541.8, so the solution spinning method will not be repeated in each embodim...

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Abstract

The invention discloses a sodium alginate / polyethylene glycol blended drug-loaded fiber with excellent mechanical properties, a preparation method and application thereof. The blended drug-loaded fiber is made by blending sodium alginate, polyethylene glycol, and salicylic acid as raw materials; the mass percentage of polyethylene glycol in the fiber is 2% to 10%, and the mass percentage of salicylic acid is The percentage content is 3% to 15%, and the mass percentage content of sodium alginate is 80% to 95%. Its preparation method is to dissolve sodium alginate and polyethylene glycol in distilled water respectively to obtain sodium alginate solution and polyethylene glycol solution with a mass percentage of 3% to 6%, and the mass ratio is sodium alginate:polyethylene glycol Alcohol: salicylic acid = 8.5-9.5: 0.2-1: 0.3-1.3 The two solutions are fully mixed with salicylic acid, filtered, degassed under reduced pressure, and prepared by solution spinning in coagulation liquid at room temperature have to. This kind of fiber has excellent mechanical properties and drug release properties, and because of its rich source of raw materials and low price, it has wide application prospects in the fields of medicine, textiles, etc., and is especially suitable for weaving non-woven fabrics as wound dressings.

Description

technical field [0001] The invention relates to a sodium alginate / polyethylene glycol blended drug-loaded fiber for making non-woven fabrics, a preparation method and application thereof, and belongs to the field of polymer materials. Background technique [0002] Sodium alginate is a natural polymer mixture, with Ca 2+ The solution is a coagulation liquid, and sodium alginate can be made into fibers by wet spinning. Ca in fiber 2+ Can interact with Na in human wound secretion + Performs ion exchange to form a wet gel on the affected area. Due to the two advantages of forming a moist wound healing environment and high human absorbability, sodium alginate dressings have been more and more widely used today. However, sodium alginate fiber has strong water absorption, and its elasticity and strength after fiber formation are not ideal, and its economic cost is also relatively high. Contents of the invention [0003] The purpose of the present invention is to provide a so...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/16D01F9/04D01D5/06A61L15/16
Inventor 杜予民王群胡先文
Owner WUHAN UNIV
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