Method of preparing concentrated pill of six ingredients with rehmannia

The technology of Liuwei Dihuang Pill and Moutan Bark is applied in the field of preparation of concentrated Liuwei Dihuang Pill, which can solve the problems of patients taking medicine inconveniently, the particle size of the original pill is small, and errors are prone to occur, and achieves shortening the dissolution time limit, increasing the surface strength, The effect of improving production efficiency

Active Publication Date: 2009-08-19
TAIJI GRP CHONGQING NO 2 CHINESE MEDICINE FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small particle size of the original pill, the drug is taken in large quantities, which makes it both troublesome and prone to errors for patients to take the medicine, which affects the curative effect

Method used

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Examples

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Effect test

preparation example Construction

[0015] The preparation method of the concentrated Liuwei Dihuang Pills of the present invention includes pretreatment, batching, milling and extraction of raw medicinal materials according to the standard. Concentrate the extracted filtrate to a relative density of 1.38-1.40 / 75°C, add ethanol or a disintegrating agent, and select an appropriate drying process to finally obtain a water content of 5-8%, a dissolution time limit of 55-120 minutes, and a dry pellet weight 0.425g~0.445g / pill, pills with a dry diameter of 8.5~9.2mm / pill.

[0016] According to the quality standards of Liuwei Dihuang Pills in the "Chinese Pharmacopoeia", although the amount of Chinese medicinal materials powdered into the powder is constant, during the extraction process, the difference between batches of medicinal materials will lead to differences in the amount of thick paste in each batch, which in turn will lead to the difference between batches of finished pills. There are certain differences in ...

Embodiment 1

[0027] Prescription: Rehmannia glutinosa 320g, Cornus officinalis (made) 160g, Peony 120g, Chinese yam 160g, Poria cocos 120g, Alisma 120g.

[0028] The preparation process is as follows: according to the prescription, take nine herbs such as Rehmannia glutinosa, Cornus officinalis, Peony, Chinese yam, Poria cocos and Alisma alisma, extract paeonol from Moutan cortex; Decoction twice, each time for two hours, the filtrate is concentrated to a thick paste with a density of 1.32-1.40, the yam and the remaining dogwood are crushed into fine powder, sieved, and mixed; then the above thick paste, fine powder, paeonol , auxiliary material mixing, the 93% ethanol that adds is made soft material, and the amount of adding ethanol is 1.2% of fine powder, medicinal extract, paeonol total amount, makes wet pill, and average pill weight is 0.477g / pill, adopts oven Dry with vibration drying, polish, get average ball diameter 8.5mm / ball, average ball weight is the product 1000 balls of 0.4...

Embodiment 2

[0030]Prescription: Rehmannia glutinosa 320g, Cornus officinalis (made) 160g, Peony 120g, Chinese yam 160g, Poria cocos 120g, Alisma 120g.

[0031] The preparation process is as follows: according to the prescription, take nine medicinal materials such as Rehmannia glutinosa, Cornus officinalis, Peony, Chinese yam, Poria cocos and Alisma alisma, extract paeonol from Moutan cortex; Decoction twice, each time for two hours, the filtrate is concentrated to a thick paste with a density of 1.32-1.40, the yam and the remaining dogwood are crushed into fine powder, sieved, and mixed; then the above thick paste, fine powder, paeonol , auxiliary material mixing, the 95% ethanol that adds is made soft material, and the amount of adding ethanol is 1.5% of fine powder, extractum, paeonol total amount, makes wet pill, and average pill weight is 0.483g / pill, adopts microwave Drying with an oven, polishing, to get an average pill diameter of 9.2mm / pill, and an average pill weight of 1000 p...

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Abstract

The invention relates to a preparation method of concentrated Liuwei Dihuang Pills, which comprises: taking rehmannia glutinosa, dogwood (manufactured), moutan cortex, Chinese yam, Poria cocos and Alisma alisma, extracting paeonol from moutan cortex; Add water to decoct Huang, Poria cocos and Alisma alisma for two times, then concentrate the filtrate to a thick paste; crush the yam and remaining dogwood into fine powder, sieve, and mix well; then mix the above thick paste, fine powder, and paeonol , after making pellets, drying, and polishing, it is characterized in that: the relative density of the filtrate thick paste is 1.38-1.40 / 75°C, the weight of the dry pellets is controlled at 0.425g-0.445g / pellet, and the diameter of the dry pellets is 8.5-9.2mm / pellet , and adding ethanol or disintegrants and improving the drying process when making soft materials. According to the research and improvement of the prior art, the present invention makes every 3 pills equivalent to 3 grams of the original drug. Not only the internal quality and appearance of the medicine meet the requirements of the standard, but also the dosage for patients is reduced and it is convenient to take.

Description

【Technical field】 [0001] The invention relates to a method for preparing traditional Chinese medicine, in particular to a method for preparing concentrated Liuwei Dihuang Wan. 【Background technique】 [0002] Liuwei Dihuang Pill is a traditional Chinese patent medicine that has the function of nourishing yin and tonifying kidney, and is used for kidney yin deficiency, dizziness and tinnitus, sore waist and knees, bone steaming hot flashes, night sweats and nocturnal emission, and quenching thirst. The process of preparing Liuwei Dihuang Pills in the prior art is as follows: take rehmannia glutinosa, dogwood (made), moutan cortex, yam, Poria cocos and Alisma alisma, extract paeonol from moutan cortex; , Poria cocos and Alisma alisma and decoct twice, then concentrate the filtrate to a thick paste with a relative density of 1.35-1.40; powder, paeonol, and auxiliary materials are mixed, and pelletized, dried, and polished to obtain concentrated pills equivalent to 3g of the ori...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/8945A61K36/884A61K36/804A61K36/71A61K36/40A61K36/076A61K47/38A61P1/14
Inventor 顾维菊程地英胡红英唐利国卿玉玲吕勇均
Owner TAIJI GRP CHONGQING NO 2 CHINESE MEDICINE FACTORY
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