Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gonadoliberin double-way genital regulating medicine and reproduction of fish

A gonadotropin and pathway technology, used in drug combinations, pharmaceutical formulations, sexually transmitted diseases, etc., can solve the problems of ineffective regulation, unguaranteed drug efficacy, intensified stress response, etc., and achieves reduction of parental ovulation death and broodstock mortality. , reduce the effect of stress response

Inactive Publication Date: 2009-06-03
宋艳
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In early spring and autumn, the temperature and water temperature are unstable, making it difficult to determine the dosage of GnRH analogues, and the efficacy of the medicine cannot be guaranteed; coupled with environmental changes, the stress response after using the medicine is intensified, often resulting in low artificial reproduction efficiency
[0008] ③ Rare fish are poorly sensitive to existing drugs
For broodstock with immature gonads, because the relevant receptors have not been formed, the drug cannot initiate the production of gonadotropins, so the drug is ineffective
[0012] ⑤Poor drug regulation, affecting large-scale reproduction
However, since SERMs only act on the lower end of the gonadal axis, they are ineffective on regulation other than estrogen receptors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gonadoliberin double-way genital regulating medicine and reproduction of fish
  • Gonadoliberin double-way genital regulating medicine and reproduction of fish
  • Gonadoliberin double-way genital regulating medicine and reproduction of fish

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] This example 1 is a gonadotropin-releasing hormone dual-path reproductive regulation drug for artificial reproduction of grass carp whose eggs have developed to stage IV. According to each kg female fish consists of the following raw materials:

[0033] Gonadotropin-releasing hormone 2 μg

[0034] Domperidone 2mg

[0035] Isoflavones and their analogs 1mg.

[0036] The artificial propagation method of using the above-mentioned medicines in fish is to dissolve gonadotropin-releasing hormone in water at normal temperature, then dissolve domperidone, isoflavones and similar substances in water and mix them, and inject them intramuscularly. The dosage is per kilogram The amount of each component added to the female fish during the ovulation period is: 1.5 μg of gonadotropin-releasing hormone, 1 mg and 0.5 mg of domperidone, isoflavones and the like; : Gonadotropin-releasing hormone 0.5μg, domperidone, isoflavones and similars 1mg, 0.5mg respectively, control the temperat...

Embodiment 2

[0038] Example 2 is a gonadotropin-releasing hormone dual-path reproductive regulation drug for artificial reproduction of white papaya. According to each kg female fish consists of the following components:

[0039] Gonadotropin-releasing hormone analog (GnRH-A) 12.5μg

[0040] Reserpine 4mg

[0041] Raloxifene 2mg.

[0042]The method of using the above-mentioned medicines for fish artificial reproduction is to dissolve gonadotropin-releasing hormone in water at room temperature, then dissolve reserpine and raloxifene in water and mix them, and inject intramuscularly. The amount of each component added to the female fish during the ovulation period is: 10 μg of gonadotropin-releasing hormone analogues, 3 mg and 0.5 mg of reserpine and raloxifene respectively; The dosage is: 2.5 μg of gonadotropin-releasing hormone analogues, 1 mg of reserpine and raloxifene respectively, controlled ripening and eutrophication water temperature is 24 ℃ ~ 32 ℃, and the dosage for each kilogr...

Embodiment 3

[0044] Present embodiment 3 is used for three flower scale fish. The fish has 28 days as a reproductive cycle, and the gonadotropin-releasing hormone dual-path reproductive regulation drug is artificially propagated in one year. According to each kg female fish consists of the following components:

[0045] GnRH 25μg

[0046] Haloperidone 220mg

[0047] Tamoxifen 220mg.

[0048] The artificial reproduction method of using the above-mentioned drugs in fish is to dissolve gonadotropin-releasing hormone in water at room temperature, then dissolve haloperidol and tamoxifen in water and mix them, and inject them intramuscularly. The dosage is 1 kg of female fish The annual total amount of each component added during the ovulation period is: 20 μg of gonadotropin releasing hormone, 200 mg of haloperidol and tamoxifen respectively; the annual total amount of each component added per kilogram of female fish during the ripening period is: gonadotropin 5 μg release hormone, 20 mg ha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A medicine for dual-approach regulation to the fish reproduction is prepared from gonadotropin-releasing hormone or its analog, dopamine antagon, and selective estrogen receptor regulator. Its application method is also disclosed.

Description

Technical field: [0001] The invention is related to reproductive regulation medicine, especially related to gonadotropin-releasing hormone dual-path reproductive regulation medicine and fish artificial reproduction method. Background technique: [0002] The positive effect of GnRH (gonadotropin-releasing hormone) is to promote (+) animal fertility (sperm, egg maturation, ovulation, ovulation), and negative feedback inhibits (-) reproduction. [0003] GnRH analogues have been widely used in fish artificial breeding to artificially induce ripening and spawning of broodstock and cultured broodstock. The purpose is to lay eggs, fertilize and hatch under artificial breeding conditions and increase the reproductive rate. However, in production practice, there are the following: question: [0004] ①Fish dystocia and death [0005] In fish artificial breeding, it is difficult for farmers to grasp the dose threshold of GnRH analogues. If the dose is insufficient, there will be no ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/22A61K45/06A61P15/00A61P15/08
Inventor 宋艳
Owner 宋艳
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com