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Medical chitosan dressing and its application

A technology of chitosan and chitosan derivatives, applied in medical science, bandages, absorbent pads, etc., can solve problems such as poor adhesion, achieve good adhesion, inhibit bacterial growth, and simple preparation process

Active Publication Date: 2008-12-17
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the hemostatic agents used in combination are coagulation factors or sodium alginate or collagen, and these water-insoluble chitosan membranes or sponges made of this have poor adhesion to skin tissue, so it still needs to be further improved and improved. Hemostatic effect and adhesion to skin tissue

Method used

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  • Medical chitosan dressing and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Preparation of Medical Chitosan Dressing A

[0008] (1) Preparation of Baiji Polysaccharide: Weigh 50 g of Chinese medicine Baiji, and grind it into small pieces. According to the method described in "Preparation of Baiji Gum", Baiji polysaccharide was prepared, and 6g of Baiji polysaccharide powder was obtained. The quality of the Chinese medicine Baiji described in this example meets the quality standard described under the item "Baiji" on pages 67-68 of the Pharmacopoeia of the People's Republic of China in 2005.

[0009] (2) Preparation of chitosan white and glue: Weigh 4 g of chitosan powder, put it in a 500 ml clean beaker, add 150 ml of 1% (V / V, the same below) acetic acid aqueous solution, stir and dissolve, and obtain chitosan Aqueous acetic acid. Weigh 0.5 g of the above-mentioned white and polysaccharide powder, put it in another 100 ml clean beaker, add 50 ml of 1% acetic acid aqueous solution, stir to dissolve, and obtain the white and polysacc...

Embodiment 2

[0014] Example 2: Preparation of Medical Chitosan Dressing B

[0015] (1) Preparation of chitosan hydroxypropyl chitin glue: Weigh 4.0 g of chitosan powder, put it in a 500 ml clean beaker, add 150 ml of 1% acetic acid aqueous solution, stir and dissolve to obtain chitosan acetic acid aqueous solution. Weigh 1.0 g of hydroxypropyl chitin powder, put it in another 100 ml clean beaker, add 50 ml of 1% acetic acid aqueous solution, stir to dissolve, and obtain an aqueous hydroxypropyl chitin acetic acid solution. The chitosan acetic acid aqueous solution and the hydroxypropyl chitin acetic acid aqueous solution are combined and stirred evenly to obtain the chitosan hydroxypropyl chitin glue.

[0016] (2) Preparation of film-like chitosan dressing B: take 60 ml of the above-mentioned chitosan hydroxypropyl chitin glue, prepare film-like chitosan dressing B according to the steps of (3) of Example 1, and obtain a film-like shell Glycan Dressing B.

[0017] (3) Preparation of Spon...

Embodiment 3

[0020] Example 3: Preparation of Medical Chitosan Dressing C

[0021] (1) Preparation of zinc chitosan: Weigh 10g of chitosan powder, put it in a 250ml clean beaker, add 150ml of deionized water, stir and suspend, slowly add 0.2g of zinc acetate under stirring, stir at room temperature for 30min, filter, Solid I was obtained. The solid I was washed three times with 150 ml of deionized water for 20 minutes each time, and filtered to obtain the solid II. The round object II was dried at 60-70° C. to obtain chitosan zinc powder.

[0022] (2) Preparation of powdery chitosan dressing C: Weigh 4 g of the above-mentioned chitosan zinc powder, put it in a mortar, and grind it finely to obtain powdery chitosan dressing C.

[0023] (3) Preparation of film-like chitosan dressing C: Weigh 2g of the above-mentioned chitosan zinc powder, put it in a 250ml beaker, add 100ml of 2% acetic acid aqueous solution, stir and dissolve to obtain a chitosan zinc colloid solution, according to the em...

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Abstract

The medical chitosan dressing is mixture of chitosan in 1 weight portion, Chinese medicine extract in 0.01-10 weight portions, chitosan derivative in 0.01-10 weight portions, and metal ion in 0.0001-0.05 weight portion. The Chinese medicine extract is bletilla tuber polysaccharide or natural indigo; and the chitosan derivative is one of hydroxypropyl chitin, hydroxypropyl chitosan, succinyl chitin, succinyl chitosan, carboxymethyl chitin and carboxymethyl chitosan. The medical chitosan dressing has the functions of promoting healing of the wound and stopping bleeding, inhibiting bacterial growth, and has excellent wound pasting performance.

Description

technical field [0001] The invention relates to a medical chitosan dressing, in particular to a medical chitosan dressing and its application in wound hemostasis, bacteriostasis and wound surface repair. Background technique [0002] Chitosan is a natural macromolecular polycationic polysaccharide with good biocompatibility, no immunogenicity, no toxic and side effects, and also has hemostatic, antibacterial, anti-infective effects, and can promote wound healing. Film-forming sheets, which endow chitosan with good properties for hemostatic dressings, bacteriostatic dressings, and wound repair dressings. It has been reported that chitosan is used as raw material to prepare wound hemostatic materials, antibacterial materials, and materials for promoting wound healing. In these studies, chitosan is usually made into water-insoluble membranes or sponges for hemostasis of wounds. However, due to the limited hemostatic effect of chitosan itself, its hemostatic effect is not idea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26
Inventor 顾其胜刘万顺韩宝芹
Owner 青岛博益特生物材料股份有限公司
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