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Medicine for treating osteoporosis and its preparation process

A technology for osteoporosis and drugs, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of high price, large side effects, easy rebound, etc., achieve significant curative effect, reduce ineffective ingredients, heavy metals, etc. volume reduction effect

Active Publication Date: 2008-05-14
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Western medicine is still in the research stage of the etiology and pathogenesis of osteoporosis, and has not yet reached an authoritative consensus. It is generally considered to be a complex result of the interaction of many factors such as genetics, hormones, nutrition, exercise, age, and immunity. Commonly used drugs In bone resorption inhibitors (such as estrogen, calcitonin, raloxifene, bisphosphonates, calcium, vitamin D, etc.) and bone formation stimulators (such as fluorine preparations, parathyroid hormone, growth hormone, Hormones, etc.), although these drugs have some effects, some curative effects are not exact, some are expensive, some have relatively large side effects, and some are easy to rebound after drug withdrawal, so they are not ideal drugs for the treatment of osteoporosis.

Method used

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  • Medicine for treating osteoporosis and its preparation process
  • Medicine for treating osteoporosis and its preparation process
  • Medicine for treating osteoporosis and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: the preparation of capsule

[0047] ingredients according to the table

[0048]

[0049] (1). According to the ratio of the seven herbs in the example ① to ⑥ in the above table, scald the Rhizoma Rhizoma Rhizoma.

[0050] (2). Soak Psoralen and Ligustrum lucidum in an ethanol solution with a concentration of 80% for about 2 hours, reflux and extract twice at 80°C, and add 10 times the concentration of the medicinal materials for the first time to 80% Extract with ethanol solution for 2.5 hours, add 8 times the concentration of medicinal material for the second time and extract with 80% ethanol solution for 2 hours, combine the two alcohol extracts, recover ethanol at 70-80°C and concentrate to a relative density of 1.08-1.20 When) the extract A, set aside. (3). Combine the five herbs of Epimedium, Lycium barbarum, Rhizoma Drynariae, Gouji, and Achyranthes bidentata with the dregs of psoraleae and Ligustrum lucidum, soak in water for 1.5 hours, decoct ...

Embodiment 2

[0051] Embodiment 2: the preparation of capsule

[0052] Psoralen 583.5g; Epimedium 583.5g; Lycium barbarum 417g; Ligustrum lucidum 417g;

[0053] Hot bone drynaria 333g; dog ridge 333g; Sichuan achyranthes bidentata 333g.

[0054] (1). Take the Qiwei medicinal materials according to the above dosage. (2). Soak the two medicinal materials of psoralen and privet fruit with a concentration of 75% ethanol solution for about 4 hours, reflux extraction at 82°C for two times, and add 10 times the concentration of medicinal materials for the first time to extract with 75% ethanol solution for 2.5 hour, the second time add 8 times the medicinal material concentration and extract with 75% ethanol solution for 2 hours, combine the alcohol extracts, reclaim ethanol and concentrate to the extract A of relative density 1.08~1.20 (at 80 ℃), for subsequent use. (3). Combine the five herbs of Epimedium, Lycium barbarum, Rhizoma Drynariae, Gouji, and Achyranthes bidentata with the dregs of p...

Embodiment 3

[0055] Embodiment 3: the preparation of tablet

[0056] The difference from Example 1 is that in step (5), 1 part of fine powder, 1.2 parts of starch, 0.3 part of dextrin, and 0.03 part of micronized silica gel are taken, and the fine powder is added to starch and dextrin, mixed evenly, granulated, and Granules, then add micropowdered silica gel, and press into tablets to obtain tablet medicine. Others are the same as embodiment 1.

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Abstract

The present invention discloses one kind of medicine for treating osteoporosis and its preparation process. The medicine is developed based on the Chinese medicine theory of benefiting liver and kidney to strengthen bones and muscles, and is prepared with seven kinds of Chinese medicinal materials, including malaytea scurfpea fruit, epimedium, wolfberry fruit, privet fruit, drynaria rhizome, cibot rhizome and cyathula root and proper amount of supplementary material. The medicine has the functions of invigorating liver and kidney, strengthening bone and relieving pain, and possesses obvious curative effect on osteoporosis and no side effect. The medicine may be prepared into different preparation forms for different clinical requirements.

Description

[technical field] [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Chinese patent medicine for treating osteoporosis and a preparation method thereof. The drug is mainly used for the treatment of liver and kidney deficiency in primary osteoporosis. [Background technique] [0002] Primary osteoporosis is a systemic bone disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and prone to fractures. This disease is a common disease in the elderly and postmenopausal women . According to the random sampling survey in Beijing in recent years, the average prevalence rate of women over 50 years old is 34%, and that of men is 25%, while the incidence rate of osteoporosis in the elderly is as high as 90.48% for women, and 60.72% for men. With the prolongation of the average life expectancy of my country's population and the aging of society, the pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K36/487A61K36/296A61K36/21A61K36/185A61K36/11A61K9/16A61K9/20A61K9/48A61P19/10
Inventor 莫新民郭建生夏新华张祝君卿光明李彦尹华勇
Owner SICHUAN MEDCO PHARML
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