Method for the treatment of urinary incontinence

a technology for urinary incontinence and urine, applied in the field of urinary incontinence treatment, can solve the problems of urine involuntarily lost, urinary incontinence, etc., and achieve the effect of decreasing the frequency of micturition

Inactive Publication Date: 2006-08-08
ENDO PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Urinary incontinence is a fairly common medical problem in which urine is involuntarily lost.

Method used

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  • Method for the treatment of urinary incontinence
  • Method for the treatment of urinary incontinence

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022]Ten female Sprague-Dawley rats having a mean weight of 263±19 g were anesthetized with urethane (1.2 g / k, sc.). A midline incision was performed to expose the bladder and a 23G catheter was inserted into the bladder dome for the measurement of intravesical pressure. A non-stop transvesical cystometrogram, as described in J. Pharmacological. Methods, 15, pp. 157-167 (1986), was used, at a filling rate of 0.216 ml / min. of saline, to access the filling and voiding characteristics of the bladder. Through the continuous cystometry method thus afforded, consecutive micturition could be recorded. Dextromethorphan was given at intravenous does of: 1.0, 3.0, 10, 30, 50 mg / kg after the initial baseline micturition sequence was reliably measured for approximately 12 min. From these recordings the absolute values in maximum pressure obtained and the frequency of micturition was measured. A dose response curve illustrating the effect of dextromethorphan on the absolute micturition pressure...

example 2

[0025]A capsule containing dextromethorphan hydrobromide contains the following ingredients:

[0026]

Ingredientmg / CapsuleDextromethorphan Hydrobromide USP20Pregelatinized Starch NF50Colloidal Silicon Dioxide1.5

example 3

[0027]A tablet containing dextromethorphan hydrobromide contains the following ingredients:

[0028]

Ingredientmg / TabletDextromethorphan Hydrobromide USP20Microcrystalline Cellulose NF17Lactose NF anhydrous68Croscarmellose NF1Colloidal Silicon Dioxide1.5Magnesium Stearate NF1.5

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PUM

PropertyMeasurementUnit
micturition frequencyaaaaaaaaaa
physical activityaaaaaaaaaa
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Abstract

Urinary incontinence is alleviated in a mammal by administering to the mammal a urinary incontinence alleviating amount of dextromethorphan, dextrorphan, their mixtures and / or pharmaceutically acceptable salts, alone or in combination with a pharmacologically active agent such as an anticholinergic, sympathomimetic, tricyclic antidepressant, antispasmodic, direct-acting smooth muscle relaxant, estrogen, compound having estrogen-like activity, or any combination of the foregoing.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 08 / 734,738 filed Oct. 21, 1996 now U.S. Pat. No. 6,562,835 which, in turn, is a divisional of U.S. application Ser. No. 08 / 398,389 filed Mar. 3, 1995, now abandoned.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a method for treating urinary incontinence.[0004]2. Description of Related Art[0005]Urinary incontinence is a fairly common medical problem in which urine is involuntarily lost. Urinary incontinence may be transient or persistent. Common causes of transient urinary incontinence include infection, atrophic urethritis, administration of diuretics and delirium. Persistent urinary incontinence is classified into four types: (1) stress incontinence which involves involuntary loss of urine during coughing, sneezing, laughing, or other physical activity; (2) urge incontinence which involves involuntary loss of urine associate...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61P3/00A61K31/485A61K9/22C07D489/00A61K9/52A61K31/565A61P13/00A61P13/02A61P13/10A61P15/00
CPCA61K31/00A61K31/565A61K31/485A61K31/46A61K31/445A61K31/35A61K31/335A61K31/215A61K31/135Y10S514/964Y10S514/963A61K2300/00A61P13/00A61P13/02A61P13/10A61P15/00A61P3/00
Inventor CARUSO, FRANK S.
Owner ENDO PHARMA INC
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