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Regeneration of tendon and tendon sheath, restoration material, and use of restoration material

a technology of tendon and sheath, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of complex freezing and thawing system, storage stability of frozen amniotic membrane, etc., and achieve the effect of reducing adhesion, good operability and easy operation

Pending Publication Date: 2021-09-16
YOSHIDA TOSHIKO +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a special method for making a medical treatment for tendon and tendon sheath injuries using a dried amniotic membrane. The treatment can restore and regenerate the tendon and tendon sheath, reduce adhesion at the sutured tendon site, and promote bone healing. This method improves the quality of life of the patient.

Problems solved by technology

On the other hand, a frozen amniotic membrane had a problem for storage stability (about 3 months at −80° C.
), that is freezing and thawing system are complicated, and so on.

Method used

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  • Regeneration of tendon and tendon sheath, restoration material, and use of restoration material
  • Regeneration of tendon and tendon sheath, restoration material, and use of restoration material
  • Regeneration of tendon and tendon sheath, restoration material, and use of restoration material

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Embodiment Construction

[0020]A dried amniotic membrane produced by a specific drying treatment is, for example, a dried amniotic membrane described in PTL 1 (hyper-dry amniotic membrane, hereinafter referred to as HD amniotic membrane). That is, during a depressurization operation, a fresh amniotic membrane placed in a treatment tank is continuously heated by an infrared heater provided. The pressure of the treatment tank is adjustment from a depressurized state to the atmospheric pressure repeatedly. During then, irradiated microwave from a microwave generator with treatment tank is drying the water molecule by applying energy. By these repeating processes, the amniotic cells are dried up, but the cell can be retained and keep structure of amniotic membrane.

[0021]A tendon is tough tissue which composed of fibers, and connecting a muscle with a bone. Particularly, a flexor tendon connecting a finger to a forearm is very important to movement of fingers and wrist. There are a finger flexor tendon which all...

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Abstract

An object is to provide a dried amniotic membrane that promotes regeneration of a tendon and a tendon sheath when a tendon injury has occurred and that reduces loss of the motor function of fingers of upper limbs and lower limbs due to tendon adhesion as a novel regeneration material. As a means for resolution, a dry amniotic membrane is produced by performing a specific drying treatment, that is, during a depressurization operation in which a fresh amniotic membrane placed in a treatment tank is continuously heated by an infrared heater provided in the treatment tank, and the inside of the treatment tank is brought into a depressurized state; and a pressure recovery operation in which the pressure of the inside of the treatment tank in a depressurized state is raised slightly toward the atmospheric pressure, drying is performed while applying energy to water molecules present in the amniotic membrane by irradiating the fresh amniotic membrane with a microwave also from a microwave generator provided in the treatment tank. The dried amniotic membrane retaining of the cell and tissue structures by repeating the treatment of drying a plurality of times promotes regeneration of the motor function of fingers of upper limbs and lower limbs after tendon suture surgery and is useful as a regeneration material.

Description

TECHNICAL FIELD[0001]The present invention relates to regeneration and restoration of a tendon and a tendon sheath, and more particularly relates to a dry amniotic membrane produced by a specific drying method as a medical material to be used for regeneration and restoration of a tendon and a tendon sheath.BACKGROUND ART[0002]An amniotic membrane is a tough biological membrane constituted by collagen and elastic fibers, and utilization thereof as a material for repairing the bladder, urethra, or ureter (PTL 1) and a membrane substitute for the cerebral dura mater, pericardium, or the like including a laminate composed of a sheet-like porous intermediate agent between two layers of collagen membrane derived from an amniotic membrane (PTL 2) have been proposed.[0003]An amniotic membrane hardly causes rejection in transplantation, and has an anti-inflammatory effect and a wound repair accelerating effect, and has been used as dressing materials for skin burn injury, repair of umbilical...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L27/36
CPCA61L27/3604A61L2430/10A61L27/3691A61L27/3662A61L2430/40
Inventor YOSHIDA, TOSHIKOOKABE, MOTONORIOSADA, RYUSUKEZUKAWA, MINEYUKIARAKAWA, MASAHIKO
Owner YOSHIDA TOSHIKO
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