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Diagnostic test for distinguishing the smoking status of a subject

a technology for diagnosing and distinguishing the smoking status of subjects, applied in the field of biological diagnostics, can solve the problems of significant pyrolysis and formation of many harmful and potentially harmful constituents (hphcs) in cigarette smoke, and achieve the effects of improving discriminatory power, convenient use, and reducing pyrolysis

Active Publication Date: 2020-05-07
PHILIP MORRIS PROD SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present patent provides a simple and cost-effective test to determine if a person smokes or not. The test involves detecting a combination of urinary total NNAL, urinary CEMA, and urinary cotinine in a person's urine. This test has improved accuracy and can detect the smoking status of certain groups of people, such as ethnical groups or age populations. The test can also be used for both mentholated and non-mentholated smoking products. Overall, this test offers an effective and easy way to assess smoking habits.

Problems solved by technology

Heating instead of burning tobacco, typically at temperatures lower than 300° C. is sufficient to release nicotine, but not high enough to cause significant pyrolysis.
Many harmful and potentially harmful constituents (HPHCs) in cigarette smoke are formed due to the combustion of tobacco.

Method used

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  • Diagnostic test for distinguishing the smoking status of a subject
  • Diagnostic test for distinguishing the smoking status of a subject
  • Diagnostic test for distinguishing the smoking status of a subject

Examples

Experimental program
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Effect test

example

[0320]This example is a randomized, controlled, open-label, 3-arm parallel group, multi-center study to demonstrate reductions in exposure to selected smoke constituents in conventional cigarettes (CC). The study included healthy smokers switching to a heat-not-burn (smoke-free alternative (SW)) product or those observing smoking abstinence (SA), compared with continuing to use CC, for 5 days in confinement and prolonged by 85 days in an ambulatory setting. This was an ad libitum smoking study. Baseline measurements are taken by allowing the subject to smoke their chosen brand of conventional cigarette for 2 days. After this 2 day period, the subject is then elected to continue smoking conventional cigarettes, to switch to a smoke-free alternative or to abstain from smoking. The investigational period then begins. Methods for measuring each of the metabolites are described in Haziza et al. (2017) Data in Brief 10, 283-293.

[0321]During the confinement period, compliance to product / re...

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Abstract

There is disclosed herein a device for determining the smoking status of a subject, wherein said device comprises a plurality of different specific binding molecules deposited to a solid phase to detect specifically the presence of two or three tobacco smoke exposure biomarkers in a biological sample, said biomarkers consisting of: (i) cotinine and total 4-(methylnitrosamino)-1-(3-, pyridyl)-1-butanol (NNAL); (ii) cotinine and N-acetyl-S-[2-carboxyethyl]-L-cysteine (CEMA); or (iii) cotinine and NNAL and CEMA.

Description

FIELD OF THE INVENTION[0001]The present invention relates, in general, to the field of biological diagnostics. In particular, the invention relates to methods, devices, systems and kits to determine or distinguish the smoking status of a subject.BACKGROUND[0002]A number of aerosol generating articles in which tobacco is heated rather than combusted have been proposed in the art. In heated aerosol generating articles, an aerosol is generated by heating a substrate, such as tobacco. Numerous studies have shown that heating tobacco to temperatures below pyrolysis and combustion temperatures has the potential to reduce or eliminate some toxicants found in cigarette smoke. Heating instead of burning tobacco, typically at temperatures lower than 300° C. is sufficient to release nicotine, but not high enough to cause significant pyrolysis. At these temperatures, the aerosol composition becomes simpler than that found in cigarette smoke. Many harmful and potentially harmful constituents (HP...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/543G01N33/94G01N21/77
CPCG01N21/77G01N33/54386G01N33/94G01N2021/775G01N33/54388
Inventor LUEDICKE, FRANKPEITSCH, MANUEL C.
Owner PHILIP MORRIS PROD SA
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