Diagnostic test for distinguishing the smoking status of a subject
a technology for diagnosing and distinguishing the smoking status of subjects, applied in the field of biological diagnostics, can solve the problems of significant pyrolysis and formation of many harmful and potentially harmful constituents (hphcs) in cigarette smoke, and achieve the effects of improving discriminatory power, convenient use, and reducing pyrolysis
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[0320]This example is a randomized, controlled, open-label, 3-arm parallel group, multi-center study to demonstrate reductions in exposure to selected smoke constituents in conventional cigarettes (CC). The study included healthy smokers switching to a heat-not-burn (smoke-free alternative (SW)) product or those observing smoking abstinence (SA), compared with continuing to use CC, for 5 days in confinement and prolonged by 85 days in an ambulatory setting. This was an ad libitum smoking study. Baseline measurements are taken by allowing the subject to smoke their chosen brand of conventional cigarette for 2 days. After this 2 day period, the subject is then elected to continue smoking conventional cigarettes, to switch to a smoke-free alternative or to abstain from smoking. The investigational period then begins. Methods for measuring each of the metabolites are described in Haziza et al. (2017) Data in Brief 10, 283-293.
[0321]During the confinement period, compliance to product / re...
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