Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Abstract

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Description

INCORPORATION BY REFERENCE TO RELATED APPLICATIONS[0001]Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16 / 453,925, filed Jun. 26, 2019, which is a continuation of U.S. application Ser. No. 14 / 145,404, filed Dec. 31, 2013, now U.S. Pat. No. 10,376,143, which is a continuation of Ser. No. 13 / 732,848, filed Jan. 2, 2013, now U.S. Pat. No. 9,763,609, which is a continuation of U.S. patent application Ser. No. 11 / 750,907, filed May 18, 2007, now U.S. Pat. No. 8,364,229. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.FIELD OF THE INVENTION[0002]The preferred embodiments relate generally to implantable devices, such as analyte sensors, and methods for detecting and / or measuring an analyte in a sample, such as a bodi...

AI Technical Summary

Benefits of technology

The patent describes an electrochemical analyte sensor that can be inserted into a host to measure the concentration of a specific analyte. The sensor has a membrane system that helps to reduce the effects of non-constant noise-causing electroactive species formed in the host. The membrane system can also include a torturous diffusion path or a resistance domain to further reduce the impact of non-constant noise-causing electroactive species. The sensor is designed to provide a signal that is at least about 80% of the signal over a time period of at least one day. Overall, the sensor has improved accuracy and reduced noise, allowing for accurate analyte concentration measurements in the host.

Problems solved by technology

In the diabetic state, the victim suffers from high blood sugar, which may cause an array of physiological derangements (for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye) associated with the deterioration of small blood vessels.

Conventionally, a diabetic person carries a self-monitoring blood glucose (SMBG) monitor, which typically comprises uncomfortable finger pricking methods.

Unfortunately, these time intervals are so far spread apart that the diabetic will likely find out too late, sometimes incurring dangerous side effects, of a hyperglycemic or hypoglycemic condition.

In fact, it is not only unlikely that a diabetic will take a timely SMBG value, but the diabetic will not know if their blood glucose value is going up (higher) or down (lower) based on conventional methods, inhibiting their ability to make educated insulin therapy decisions.

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