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Thermogelling supramolecular sponge as self-healing and biocompatible hydrogel

a biocompatible hydrogel and supramolecular technology, applied in the direction of prosthesis, pharmaceutical non-active ingredients, additive manufacturing apparatus, etc., can solve the problems of major application and further development limitations, shortfall of suitable and versatile bioinks, etc., to improve thermogelling and rheological properties

Inactive Publication Date: 2019-05-23
JULIUS MAXIMILIANS UNIV WURZBURG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The present invention provides a material with improved thermogelling and rheological properties due to their specific structural composition. The block copolymers form transparent hydrogels with high strength and show excellent and rapid shear recovery after stress. The polymers are easy and scalable to synthesize and the gelation process is fast. The material is highly cytocompatible, giving relatively stable hydrogels, but shows pronounced shear thinning. The usage of the block copolymers in different applications such as drug delivery, cell delivery, and protein delivery is favored due to the thermogelling and hydgel properties. The hydrogels formed from the polymers are optically transparent, which further enhances their suitability for various applications.

Problems solved by technology

In the upcoming field of biofabrication, a shortage of suitable and versatile bioinks represents a major limitation to application and further development to date.

Method used

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  • Thermogelling supramolecular sponge as self-healing and biocompatible hydrogel
  • Thermogelling supramolecular sponge as self-healing and biocompatible hydrogel
  • Thermogelling supramolecular sponge as self-healing and biocompatible hydrogel

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Embodiment Construction

[0107]Reference will now be made in detail to the preferred embodiments of the present invention. It is to be understood that the following examples are illustrative only and the present invention is not limited thereto.

[0108]Several batches (P1 to P5) of Methyl-P[nPrOzi50-b-MeOx50]-piperidine-4-carboxylic acid ethyl ester (poly(nPrOzi)-b-poly(MeOx) were analyzed using gel permeation chromatography (GPC) (FIG. 1), temperature dependent rheological properties (FIG. 2) and 1H-NMR spectra (FIGS. 3 to 7). The results are first of all summarized in following Table 1:

TABLE 1Degree of Polymerization (DP) and molar masses (kg / mol) obtained by NMR and GPC of batches P1 to P5. DP theo•DPexp[a]Mn theo•Mn[b]Mw[b]Ð[b]P152 / 5242 / 4411.210.014.91.49P250 / 5057 / 5510.87.38.51.17P350 / 5051 / 5110.86.38.11.29P450 / 5855 / 5011.56.48.21.28P551 / 4944 / 4510.86.57.81.22[a]Determined by end-group analysis (1H NMR spectroscopy in MeOD-d4 (300 MHz, 298 K));[b]Determined from GPC in DMF with LiBr (1 g / L) at 313K.

[0109]FIG...

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Abstract

Block copolymers have a general chemical structure of one of the formulas [A]n-[B]m and [B]n-[A]m, wherein [A] is a poly(2-oxazine) and wherein [B] is a poly(2-oxazoline). The block copolymers have desired thermogelling and rheological properties and are useful as carrier materials for active ingredients such as drugs, cells, proteins, and other active ingredients.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation, under 35 U.S.C. § 120, of co-pending International Patent Application No. PCT / EP2017 / 062982, filed May 30, 2017, which designated the United States. This application also claims the priority, under 35 U.S.C. § 119, of European Patent Application No. EP 1618 0838.1, filed Jul. 22, 2016. The priority applications are each incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]This application is directed to block copolymers with improved thermo-gelling and rheological properties due to their specific structural composition.BACKGROUND OF THE INVENTION[0003]Biocompatible polymers that form thermoreversible supramolecular hydrogels have gained great interest recently as so-called bioinks for 3D bioprinting in tissue engineering and biofabrication.[0004]For example, thermogelling polymers find application in food and pharmaceutical technology, biology, and medicine (J. D. Kretlow, S. Y...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08G73/02C08J3/075A61K47/59A61L27/18A61L27/44A61L27/38B33Y70/00
CPCC08G73/0233C08J3/075A61K47/59A61L27/18A61L27/44A61L27/38B33Y70/00C08J2379/02C08J2379/04
Inventor LORSON, THOMASLUXENHOFER, ROBERT
Owner JULIUS MAXIMILIANS UNIV WURZBURG
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