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Implants for sculpting, augmenting or correcting facial features such as the chin

a technology for chin retrusion and facial features, applied in the field of injectable compositions, can solve the problems of reducing the cohesion of the composition to the point that it is difficult to inject with a thin needle, affecting the chin retrusion correction, and all the drawbacks of these treatment methods, so as to achieve the effect of high cohesion and elasticity

Inactive Publication Date: 2018-08-23
ALLERGAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a way to make a temporary, reversible gel made from hyaluronic acid that can be used to add volume and contour to the face. The gel has a high resistance to deformation, making it easier to inject with a thin needle. The gel can be shaped and molded after injection, which allows for more precise shaping and contouring of the face. The invention is useful for improving the appearance of wrinkles, folds, and chin deformities.

Problems solved by technology

One of the drawbacks of maximizing these resistances, for example, elasticity and cohesivity, is that it is expected that in doing so, the viscosity of the compositions will increase to the point that they become difficult to inject with a thin needle.
However, all of these treatment methods have drawbacks.
For example, chin implants and genioplasty involve painful surgery that may not result in correction of chin retrusion and aesthetic blending of the area.
This approach may exacerbate bone resorption and infection, resulting in the need for implant removal.

Method used

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  • Implants for sculpting, augmenting or correcting facial features such as the chin
  • Implants for sculpting, augmenting or correcting facial features such as the chin
  • Implants for sculpting, augmenting or correcting facial features such as the chin

Examples

Experimental program
Comparison scheme
Effect test

example 1

Manufacture of an Injectable Implant in Accordance with an Embodiment of the Invention

[0081]Predried fibers of sodium hyaluronate (NaHA) (0.9 g) having a molecular weight of about 0.9 MDa is weighed out into a first receptacle.

[0082]Predried fibers of NaHA (0.1 g) having a molecular weight of about 3.0 MDa is weighed out into a second receptacle.

[0083]The two different grades of NaHA are combined and diluted into a 1% sodium hydroxide solution and mixed for one to two hours at between 20° C. and 50° C. to obtain a substantially homogenous, alkaline HA gel.

[0084]In a separate receptacle, the chosen crosslinking agent, 1,4-butanediol diglycidyl ether (BDDE), is diluted into a 1% sodium hydroxide solution to a final concentration of 10% BDDE (wt / wt).

[0085]To the alkaline HA gel was added 10% (wt / wt) BDDE (1 g of the previously prepared BDDE solution). The resulting mixture is mechanically homogenized.

[0086]The mixture is then maintained at 50° C. for 3 to 4.5 hours.

[0087]The resulting ...

example 2

Method for Increasing the G Sn Pog Facial Angle in a Subject Having Chin Retrusion or a Weak Chin

[0100]A composition of the invention is administered as an injectable implant, by subdermal or supraperiosteal injection in the chin and / or jaw area of a 32 year old male subject. The subject complains he has a “weak chin”. The doctor measures the subject's facial angle and determines that the a G-Sn-Pog angle of about 150°, which is substantially lower than the classic Burstone angle of the average chin (approximately 169°). The measurement is based on calculations of facial angle derived from digital images obtained using Canfield imaging equipment and software.

[0101]The doctor considers the subject's chin / jaw retrusion to be amenable to correction with a treatment goal consistent with increasing chin projection horizontally (in the profile view), not chin lengthening or widening.

[0102]The doctor believes that he can provide the subject with a more attractive facial profile and a stron...

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Abstract

An injectable device, comprising a hyaluronic acid-based composition, useful for long lasting facial sculpting and correction of facial features, for example, for augmenting and shaping the profile, including for example, the chin, jawline or the nose, in a human being is provided. Methods of treatment are also provided.

Description

[0001]The present invention generally relates to injectable compositions and more specifically relates to injectable implants for adding structure and contour to the lower face.[0002]Dermal fillers are injectable, biocompatible compositions which are well known to correct wrinkles and folds and add volume to the face. Hyaluronic acid (HA) is still considered by many to be one of the most desirable dermal fillers in that it does not pose the risk of an allergic reaction and it is temporary and reversible. The great majority of hyaluronic acid-based dermal fillers have been specifically developed for treating wrinkles and folds in skin. To be useful for facial contouring or substantial volumizing, it would be advantageous to increase the bulking effect of the compositions, also referred to as “lift”. It would also be advantageous to maximize resistances of the compositions to shear and normal deformation happening in the soft tissues of the face. One of the drawbacks of maximizing the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L27/20A61M5/32A61L27/52C08B37/08A61L27/54A61L27/12
CPCA61L27/20A61M5/329A61L27/52C08B37/0072A61L27/54A61L27/12A61L2400/06A61L2300/402A61L2300/216C08L5/08A61L27/3691A61F2/0059A61L2430/02A61L27/50
Inventor ROCA MARTINEZ, JEAN-XAVIERAYGLON, AURORE
Owner ALLERGAN IND
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