Oral Compositions and Methods of Use

Abstract

Described herein are oral care compositions comprising an amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a molecular weight of from about 300,000 to about 350,000; and a polysaccharide gum; along with methods of making and using same.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of priority from PCT / CN2016 / 086994, filed Jun. 24, 2016, the contents of which are hereby incorporated by reference in their entirety.BACKGROUND[0002]Arginine-based oral care compositions generally include some combination of polymers, abrasive(s); and in some instances, additional active ingredients. In those instances where additional active ingredients are included and comprise cationic metal ions, e.g. zinc, maintaining the physical stability of the composition is a challenge because of the interaction between these cationic metal ions and certain polymeric components and abrasive systems.[0003]The use of certain abrasives or specific concentrations of particular polymers are two ways in which the stability issues have been addressed. However, these methods have generally been individually focused on stand-up (i.e., appearance on the brush) and squeezability from packaging (toothpaste tubes). As such...

AI Technical Summary

Benefits of technology

[0006]In some embodiments, the oral care compositions of the present invention demonstrate the ability to avoid viscosity loss and maintain static yield stress over an extended period of time, e.g. after one year.

[0121]1.94 Any of the preceding compositions effective upon application to the oral cavity, e.g., by rinsing, optionally in conjunction with brushing, to (i) reduce or inhibit formation of dental caries. (ii) reduce, repair or inhibit pre-carious lesions of the enamel, e.g., as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM), (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce levels of acid producing bacteria, (viii) to increase relative levels of arginolytic bacteria, (ix) inhibit microbial biofilm formation in the oral cavity, (x) raise and / or maintain plaque pH at levels of at least pH 5.5 following sugar challenge, (xi) reduce plaque accumulation, (xii) treat, relieve or reduce dry mouth, (xiii) clean the teeth and oral cavity (xiv) reduce erosion, (xv) prevents stains and / or whiten teeth, (xvi) immunize the teeth against cariogenic bacteria; and / or (xvii) promote systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues.

[0138]xii. enhance systemic health, including cardiovascular health,e.g., by reducing potential for systemic infection via the oral tissues,

Problems solved by technology

In those instances where additional active ingredients are included and comprise cationic metal ions, e.g. zinc, maintaining the physical stability of the composition is a challenge because of the interaction between these cationic metal ions and certain polymeric components and abrasive systems.

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