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Disinfectant Composition with Rapid Antiviral Efficacy

a technology of disinfectant composition and rapid antiviral effect, which is applied in the direction of antivirals, chemicals, medical preparations, etc., can solve the problem that most disinfectants have insufficient antiviral efficacy against these types of non-enveloped viruses, and achieve the effect of reducing virus infectivity

Inactive Publication Date: 2018-07-19
KIMBERLY-CLARK WORLDWIDE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a disinfectant composition that can effectively kill viruses. The composition contains a primary antiviral agent, which is a polyprotic acid with a low acid dissociation constant, a secondary antiviral agent, which can be anionic N-acyl compounds, metal halide salts, amine compounds, etc., and a solvent system that includes water and other solvents. The composition has a low pH and can reduce virus infectivity by at least 30% after being exposed to a non-enveloped virus for 10 minutes. This invention is useful in preventing the spread of viruses and keeping surfaces clean.

Problems solved by technology

Thus, most disinfectants have insufficient efficacy against these types of non-enveloped viruses.

Method used

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  • Disinfectant Composition with Rapid Antiviral Efficacy
  • Disinfectant Composition with Rapid Antiviral Efficacy
  • Disinfectant Composition with Rapid Antiviral Efficacy

Examples

Experimental program
Comparison scheme
Effect test

example

[0106]Various formulations were formed as set forth in the table below. Once formed, the virus infectivity was tested according to the method described above. The results are set forth below.

Secondary Secondary Antiviral Agent in Combination Antiviral Agentwith Primary Antiviral Agent (% values Alonerepresent reduction in virus infectivity)Concen-Concen-MaleicPhosphoricSulfosuccinicSecondary tration% trationAcidAcidAcid Antiviral Agent(mM)Reduction(mM)(3 mM)(50-150 mM)(10-32 mM)None———1-8%0-47%0-75%Plantacare 818 UP2 5%3099% 6% 0%(Cocoglucoside)6 0%50 0% 0% 0%17 0%60 0% 0% 0%51 0%80 0% 0% 0%Hostapon TPHC25 0%25 0%99%99%(Sodium Methyl42 0%42 0%96%88%Oleoyl Taurate)50 0%50 0%99%50%67 0%67 0%99% 1%Genaminox CHE30 0%30 0%——(Coco dihydroxy51 0%51 0%——ethyl amine oxide)61 0%61 0%——81 0%81 0%——Mackamine C-106 7%3010% 0% 6%(Decylamine 18 4%4935% 0% 0%oxide)5311%5964% 0% 2%18330%7962% 0% 0%Ammonyx LMDO2 5%3032% 0% 0%(Lauramidopropyl-611%5097% 0% 0%amine Oxide)17 0%61 0% 0% 0%50 0%81 0% 0% 0%...

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Abstract

A disinfectant composition that contains a unique combination of a primary antiviral agent and a secondary antiviral agent is provided. More particularly, the primary antiviral agent includes a polyprotic acid having a low first acid dissociation constant and the secondary antiviral agent is selected from the group consisting of an anionic N-acyl compound, metal halide salt, amine compound, amine compound, aliphatic amine oxide, alkyl glycoside, alcohol ethoxylate, and combinations thereof. By selectively controlling the particular nature of each antiviral agent and their relative concentration, the present inventors have discovered that a synergistic affect can be achieved in which the disinfectant composition is capable of exhibiting an antiviral efficacy against non-enveloped viruses.

Description

BACKGROUND OF THE INVENTION[0001]Pathogenic viruses are generally classified into two general types: enveloped and non-enveloped viruses. Some well-known enveloped viruses include herpes virus, influenza virus; paramyxovirus, respiratory syncytial virus, coronavirus, HIV, hepatitis B virus, hepatitis C virus, and togavirus. Non-enveloped viruses, sometimes referred to as “naked” viruses, include the families Picornaviridae, Reoviridae, Caliciviridae, Papovaviridae, Adenoviridae and Parvoviridae. Members of these families include rhinovirus, poliovirus, adenovirus, hepatitis A virus, norovirus, coxsackievirus, enterovirus, papillomavirus, and rotavirus. “Enveloped” viruses are relatively sensitive and, thus, can be inactivated by commonly used disinfectants. In contrast, “non-enveloped” viruses are substantially more resistant to conventional disinfectants and are more environmentally stable than enveloped viruses. Thus, most disinfectants have insufficient efficacy against these typ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L2/18A61K31/194A61K31/205A61K31/661A61P31/12
CPCA61L2/18A61K31/194A61K31/205A61K31/661A61P31/12A61K45/06Y02A50/30A61K2300/00A61P31/00
Inventor HOFFMAN, DOUGLAS R.VANDEN HEUVEL, AMY L.PAULSEN, JEREMY D.ANUNSON, PAIGE N.KROLL, LISA M.CUNNINGTON, COREY T.KOENIG, DAVID W.
Owner KIMBERLY-CLARK WORLDWIDE INC
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