Silicone-based biophotonic compositions and uses thereof

a biophotonic composition and silicon-based technology, applied in the field of silicon-based biophotonic compositions, can solve the problems of low therapeutic efficacy of existing regimens, poor selectivity, and associated undesired side effects, and achieve the effects of promoting wound healing, promoting tissue repair, and promoting wound healing

Active Publication Date: 2017-07-27
FLE INT SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0024]From another aspect, there is provided a method for promoting wound healing comprising: placing a silicone-based biophotonic composition of the disclosure on or over a wound and illuminating said silicone-based biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the at least one chromophore. In some embodiments, the biophotonic composition emits fluorescence at a wavelength and intensity that promotes wound healing.
[0025]From another aspect, there is provided a method for biophotonic tissue repair comprising: placing a silicone-based biophotonic composition of the disclosure on or over a target tissue; and illuminating said silicone-based biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the at least one chromophore. In some embodiments, the biophotonic composition emits fluorescence at a wavelength and intensity that promotes tissue repair.

Problems solved by technology

Such regimens, however, are often associated with undesired side-effects, including systemic or localized toxicity to the patient or damage to non-targeted tissue.
Moreover, such existing regimens often demonstrate low therapeutic efficacy due to, for example, the poor selectivity of the photosensitive agents into the target tissues.

Method used

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  • Silicone-based biophotonic compositions and uses thereof
  • Silicone-based biophotonic compositions and uses thereof
  • Silicone-based biophotonic compositions and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Silicone-Based Biophotonic Composition (25% Pluronic-F127)

[0187]Preparation of 25% wt % Pluronic-F127 solutions (Surfactant Phase) Typical preparation of thermogelling solutions of Pluronic comprised dissolving a measured mass of Pluronic F-127 in a measured volume of cold, de-ionised water (−4° C.). The concentration of Pluronic is expressed in weight per volume of H2O.

[0188]Thus, for the preparation of a stock thermogelling Pluronic solution (25% w / v), a mass of 25.00 g of Pluronic F-127 was added, under magnetic stirring, to 100 mL of H2O in an

[0189]Erlenmeyer flask of 250 mL. The Erlenmeyer with the solution was then cooled in an ice bath (between 2 and 4° C.), while continuing stirring for about 1 hour, until complete dissolution of the Pluronic F-127. The resulting solution was then stored in the fridge at about 4° C.

[0190]A gelation test was performed which indicated that the solution formed into a hydrogel after approximately 5 minutes at room temperature (−22° C.).

Preparati...

example 2

Cytokines and Growth Factors in DHF

[0196]In order to gain a more detailed picture of the biological effect mediated by the silicone-based biophotonic membrane of Example 1 (second experiment), Human Cytokine Antibody Array (RayBio C-Series, RayBiotech, Inc.) was performed. Cytokines broadly defined as secreted cell-cell signaling proteins play important roles in inflammation, innate immunity, apoptosis, angiogenesis, cell growth and differentiation. Simultaneous detection of multiple cytokines provides a powerful tool to study cell activity. Regulation of cellular processes by cytokines is a complex, dynamic process, often involving multiple proteins. Positive and negative feedback loops, pleiotrophic effects and redundant functions, spatial and temporal expression of or synergistic interactions between multiple cytokines, even regulation via release of soluble forms of membrane-bound receptors, are all common mechanisms modulating the effects of cytokine signaling.

[0197]DHF (Derman...

example 3

Proliferation Level in DHF Cells Upon Illumination by a Silicone-Based Biophotonic Membrane

[0202]In order to gain more detailed picture of the biological effect mediated by the silicone-based biophotonic membrane of Example 1 (second experiment) and its implication in a wound healing process, cellular proliferation was assessed in Human Dermal Fibroblast (DHF) experimental system. In tissues, within four-five days upon injury, matrix-generating cells i.e. fibroblasts, move into the granulation tissue. Their migration to and proliferation within the wound site are prerequisites for wound granulation and consecutive healing. Fibroblasts then participate in the construction of scar tissue and its remodeling. Thus viable, actively dividing fibroblast are crucial player in healing progression.

[0203]The present experiment utilized an XTT assay to measure cell viability. The XTT-based method measures the mitochondrial dehydrogenase activity of proliferating cells. In brief, the mitochondri...

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Abstract

The present disclosure provides silicone-based biophotonic compositions and methods useful in phototherapy. In particular, the silicone-based biophotonic compositions of the present disclosure include a silicone phase and a surfactant phase, wherein the surfactant phase comprises at least one chromophore solubilized in a surfactant. The silicone-based biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and scarring, as well as various other skin disorders.

Description

REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 62 / 009,870, filed Jun. 9, 2014, the disclosure of which is incorporated herein by reference in its entirety.BACKGROUND OF THE DISCLOSURE[0002]Phototherapy has recently been recognized as having wide range of applications in both the medical and cosmetic fields including use in surgery, therapy and diagnostics. For example, phototherapy has been used to treat cancers and tumors with lessened invasiveness, to disinfect target sites as an antimicrobial treatment, to promote wound healing, and for facial skin rejuvenation.[0003]Photodynamic therapy is a type of phototherapy involving the application of a photosensitive agent to target tissue then exposing the target tissue to a light source after a determined period of time during which the photosensitizer is absorbed by the target tissue. Such regimens, however, are often associated with undesired side-effects, including syste...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/80A61K41/00A61K8/891A61K8/86A61N5/06A61K47/20A61K8/41A61K47/18A61K9/00A61K47/10A61K8/46
CPCA61K31/80A61N2005/0651A61K41/008A61K8/891A61K8/86A61K8/463A61K47/20A61K8/416A61K47/186A61K9/0014A61N5/0616A61N5/062A61K2800/48A61K2800/52A61K2800/81A61K2800/596A61N2005/0662A61K47/10A61K41/00A61K47/34A61K31/352A61L26/0095A61K8/498A61K8/731A61Q19/00A61Q19/08A61K8/895A61K8/90A61K9/1075A61K9/7015A61L26/0061A61K2800/434A61P17/00A61P17/02A61P17/06A61P17/10A61P29/00C08L83/04C08L71/02
Inventor PIERGALLINI, REMIGIOLOUPIS, NIKOLAOSJAWORSKA, JOANNADEVEMY, EMMANUELLEDESROSIERS, ERICCHENITE, ABDELLATIF
Owner FLE INT SRL
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