Implantable Tissue Structure Modifiers and Methods for Using the Same

Abstract

Implantable tissue structure modification devices are provided. Aspects of the tissue structure modification devices include first and second tissue securers separated by a contraction region, wherein the device is configured to be implanted at a cardiac location and assume a first constrained length that is longer than a second relaxed length. Also provided are methods of using the devices for tissue structure modification, as well as delivery systems and kits that find use in the methods. The devices and methods of the invention find use in a variety of different applications, including valve (e.g., mitral valve) structure modification.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]Pursuant to 35 U.S.C. §119(e), this application claims priority to the filing date of the U.S. Provisional Patent Application Ser. No. 61 / 302,367 filed Feb. 8, 2010; and to the filing date of the U.S. Provisional Patent Application Ser. No. 61 / 263,018 filed Nov. 20, 2009; the disclosures of which applications are herein incorporated by reference.INTRODUCTION[0002]The mitral valve is a heart valve composed of two leaflets (anterior and posterior) demarcated by two commissures along an annular ring. The mitral valve separates the left atrium from the left ventricle, and functions as a regulator for the entrance of blood from the left atrium into the left ventricle. The valve opens during diastole to allow oxygenated blood to flow from the left atrium into the left ventricle. The mitral valve doses during systole (with the two leaflets co-apting and forming a seal), while the aortic valve simultaneously opens, allowing blood to escape the co...

AI Technical Summary

Benefits of technology

The patent is about devices and methods for modifying the structure of tissue, such as heart valves, by using two securers that can be implanted at a cardiac location. The devices can be designed to have a longer length when first implanted and a shorter length when relaxed. The invention can be used in various applications for heart valve modification.

Problems solved by technology

Mitral regurgitation may lead to congestive heart failure.

In addition, valve repair and replacement is typically technically challenging and requires a substantial incision through a heart wall to access the valve.

Most patients with mitral regurgitation are not even considered candidates for heart valve surgery because of the high risk involved.

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