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Compositions comprising amino acids for prevention and/or treatment of renal disorders

a technology of amino acids and compositions, applied in the direction of biocide, drug compositions, peptide/protein ingredients, etc., can solve the problems of increasing the susceptibility of healthy subjects as well as those with chronic diseases to drugs and electrolyte abnormalities, and the degree of dangerous protein malnutrition in these patients, and achieves low cost and high tolerability of compositions

Inactive Publication Date: 2013-09-12
DETERMINANTS OF METABOLISM RES LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventor discovered that a combination of certain free amino acids can effectively prevent and treat kidney diseases in mammals, particularly in elderly subjects. The composition is tolerable to chronic use and can help restore kidney function. The use of free amino acids is cost-effective and can also be obtained through genetic engineering or other methods.

Problems solved by technology

Although human kidneys age better than other fundamental organs, such as the heart and brain, their decline in structure and function increases the susceptibility of healthy subjects as well as those with chronic disease to drugs and electrolyte abnormalities during stressful conditions.
Chronic kidney diseases (CKD) and their progression to end-stage renal disease (ESRD) are considerable social and economic problems in all industrialized countries.
Low (LPD) or very low (VLPD) protein diets have been widely used, first for treating uremia and then to prevent the progression of CKD, but recently, a meta-analysis of existing data concluded that there is no evidence that LPD or VLPD diets have any effect in reducing the progression of kidney disease in diabetic nephropathy, and very often some degree of dangerous protein malnutrition occurs in these patients.

Method used

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  • Compositions comprising amino acids for prevention and/or treatment of renal disorders
  • Compositions comprising amino acids for prevention and/or treatment of renal disorders
  • Compositions comprising amino acids for prevention and/or treatment of renal disorders

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Embodiment Construction

[0018]In the following description, numerous specific details are given to provide a thorough understanding of embodiments. The embodiments can be practiced without one or more of the specific details, or with other methods, components, materials, etc. In other instances, well-known structures, materials, or operations are not shown or described in detail to avoid obscuring aspects of the embodiments.

[0019]Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

[0020]The headings provided herein are for...

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Abstract

Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prophylactic and / or therapeutic treatment of renal disorders in a subject, preferably an elderly subject.

Description

FIELD OF THE INVENTION[0001]The present invention regards compositions for prevention and / or treatment of renal disorders in mammals. More specifically, the present invention concerns the use of compositions for prevention and / or treatment of renal disorders comprising natural and non-natural amino acids preferably in an elderly subject.BACKGROUND[0002]Although human kidneys age better than other fundamental organs, such as the heart and brain, their decline in structure and function increases the susceptibility of healthy subjects as well as those with chronic disease to drugs and electrolyte abnormalities during stressful conditions. Chronic kidney diseases (CKD) and their progression to end-stage renal disease (ESRD) are considerable social and economic problems in all industrialized countries.[0003]Each year in Italy, more than 18,000 patients are diagnosed as having CKD, and about a half million Italians have serum creatinine levels higher than 1.5 mg / dL. The incidence of CKD i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/198A61K31/405A61K31/4172
CPCA23L1/3051A23V2002/00A61K31/198A61K45/06A61K31/4172A61K31/405A61K2300/00A23V2250/0628A23V2250/0626A23V2250/0654A23V2250/0648A23V2250/063A23L33/175A61P13/12
Inventor CONTI, FRANCODIOGUARDI, FRANCESCO SAVERIO
Owner DETERMINANTS OF METABOLISM RES LAB
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