Surfactant Mixtures for Improving the Deposition of Active Substances and for Reducing the Skin Irritant Action

Abstract

A cosmetic or pharmaceutical rinse-off formulation contains 0.2% by weight to 20% by weight of a phase A; 0.1% by weight to 50% by weight of an active substance; a detergent; and the remainder being water. The phase A is a mixture of 20% by weight to 90% by weight of a surfactant mixture of isethionates, acyl lactylates and one of alkyl glutamates and alkyl glucosides and 10% by weight to 80% by weight of water, alcohol, polyol or mixtures thereof. The phase A forms multilamellar vesicles. The cosmetic or pharmaceutical rinse-off formulation is a clear product with the multilamellar vesicles of phase A having an average diameter of less than 100 nm.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of application Ser. No. 10 / 555,414 having a filing dated of Oct. 12, 2006, said application being a national stage filing of international application No. PCT / EP2004 / 04863 having an international filing date of 06 May 2004 and designating the United States, said international application claiming a priority date of 07 May 2003 based on prior filed international application PCT / EP2003 / 04788, the entire contents of the aforesaid application Ser. No. 10 / 555,414 and the aforesaid international applications being incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]The invention relates to the use of mixtures of surfactants for reducing the skin irritant action of cosmetic and / or pharmaceutical formulations which are applied to the skin. Additionally, the surfactant mixtures should serve for the targeted encapsulation and improvement in the application of active substances to the skin. Here, active...

AI Technical Summary

Benefits of technology

[0008]The objects are achieved according to the invention by the use of mixtures of surfactants which form multilamellar liquid-crystalline structures, where the surfactants are chosen from at least two of the following groups formed from isethionates, taurates, sarcosinates, acyl lactylates, acyl glutamates, fatty acid-protein condensates, PEG stearates, PEG distearates with an HLB value of less than 10, alkyl polyglycosides and betaines for reducing the skin irritant effect of cosmetic and / or pharmaceutical formulations which are applied to the skin, and for improving damaged hair structures.

[0009]The objects are additionally achieved according to the invention by using mixtures of surfactants which form multilamellar liquid-crystalline structures, where the surfactants are chosen from at least two of the following groups formed from isethionates, taurates, sarcosinates, acyl lactylates, acyl glutamates, fatty acid-protein condensates, PEG stearates, PEG distearates with an HLB value of less than 10, alkyl polyglycosides and betaines in cosmetic and / or pharmaceutical formulations which comprise active substances which are chosen from organic photoprotective filters, antidandruff active substances, keratolytics and other pharmaceutical active substances, antioxidants, plant extracts, oils, waxes, and mixtures thereof, for improving the application of the active substances to the skin.

Problems solved by technology

This procedure has the disadvantage that in most cases upon use only small amounts of the active substances remain on the skin, which can develop their effect there.

This leads to large amounts of costly active substances having to be incorporated into the formulations in order to achieve a desired effect.

However, when suitably high amounts of active substances are used in the rinse-off formulations, an undesired skin irritation is often observed when the formulations are used.