Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Low Viscosity, Highly Flocculated Triamcinolone Acetonide Suspensions for Intravitreal Injection

a triamcinolone acetonide and suspension technology, applied in the field of injection formulations, to achieve the effect of convenient resuspension, excellent settling characteristics, and smooth and easy injection

Inactive Publication Date: 2012-05-10
ALCON RES LTD
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005]The present invention provides improved triamcinolone acetonide suspension compositions that are particularly suited for injection into the eye. The improved aqueous suspension compositions have excellent settling characteristics, are easily resuspended with gentle-shaking, are preservative-free, and are capable of being smoothly and easily injected through 30-gauge needles. In addition, the suspension compositions of the present invention can be terminally sterilized by autoclaving. The suspension compositions are also suitable for poorly soluble drugs other than triamcinolone,

Problems solved by technology

(i.e., benzyl alcohol) because the preservative may be irritating to the vitreous and tissues in the posterior segment of the eye.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0043]The composition of Kenalog®-40 is shown in Table 1.1 below. It contains 4% triamcinolone acetonide and 0.04% polysorbate 80. The viscosity of this suspension is about 14 cps.

[0044]The particle size data for several lots was measured by laser light diffraction (Microtrac® S3000) and is shown in Table 1.2. The median particle size of the various lots of Kenalog-40 ranged from 13 to 22 μm.

[0045]The force required to extrude the Kenalog®-40 suspension through a one-half inch 30 gauge needle attached to a 1 mL tuberculin syringe is provided in Table 1.3. The results show that Kenlaog-40 suspension plugged the 30 gauge needle. The force required was quite variable and high. The plugging of the needle is due to the large particle size of this suspension.

[0046]The Kenalog®-40 suspension composition was determined to have a final sediment volume of about 14% and therefore has a Degree of Flocculation of 3.5. Thus, this suspension is only lightly flocculated, relative to the suspension ...

example 2

[0047]Triamcinolone acetonide suspensions with different concentrations of polysorbate 80 but without CMC were prepared as shown in Table 2.1. The mean volume particle size of the triamcinolone acetonide substance used in these compositions was 5-6 μm (measured using a Microtrac® S3000 instrument).

[0048]A settling study was carried out on these formulations by placing 10 mL samples of each of them in separate 10 mL graduated cylinders and recording sediment volume as a function of time. Kenalog®-40 was studied as a control. The results are provided in Table 2.2. These results show that 4% triamcinolone formulations with polysorbate 80 concentrations less than 0.02% have high final sediment volumes. For these compositions, the sediment volume stabilized within a day and did not change for 7 days. The Degree of Flocculation for these samples ranged from 9.5 to 13.5, indicating that the compositions are highly flocculated. However, the formulations with a polysorbate 80 concentration o...

example 3

[0049]Compositions of 4% triamcinolone acetonide suspensions with 0.015% polysorbate 80 and different concentrations of CMC are described in Table 3.1 below. The mean volume particle size of the triamcinolone acetonide substance used in these compositions was 5-6 μm (measured using a Microtrac® S3000 instrument).

[0050]A settling study was carried out on these formulations by placing 10 mL samples of each of them in separate 10 mL graduated cylinders and recording sediment volume as a function of time. The results are provided in Table 3.2. The Degree of Flocculation in every case is >10. Thus, these compositions are representative examples of the highly flocculated compositions of the present invention.

TABLE 3.1Compositions of Triamcinolone Injection With CMCCompositionGHIJTriamcinolone4%4%4%4%Polysorbate 800.015%0.015%0.015%0.015%Carboxymethylcellulose0%0.25%0.5%0.75%sodium (7LFPH)Sodium Chloride0.64%0.64%0.64%0.64%Potassium Chloride0.075%0.075%0.075%0.075%Calcium Chloride (Dihydra...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection.

Description

FIELD OF THE INVENTION[0001]The present invention relates to injectable formulations used for treating diseases or conditions of the eye. More particularly, the present invention relates to suspension formulations that have a low viscosity and are highly (i.e. loosely) flocculated. The suspension formulations comprise the steroid triamcinolone or other poorly soluble drug compound.BACKGROUND OF THE INVENTION[0002]Injectable compositions containing triamcinolone acetonide have been available for many years. Commercial products include Kenalog®-10 Injection (triamcinolone acetonide injectable suspension, USP) and Kenalog®-40 Injection (triamcinolone acetonide injectable suspension, USP), which are marketed by Bristol-Myers Squibb Co. These products contain 10 mg / ml or 40 mg / ml of triamcinolone acetonide, respectively. According to its package insert, Kenalog-40 Injection is approved for certain intramuscular and intra-articular uses. Where oral therapy is not feasible or is temporaril...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/58A61P27/02A61K31/496
CPCA61K9/0048A61K9/10Y10S514/913A61K47/34Y10S514/912A61K31/58A61P27/00A61P27/02
Inventor KABRA, BHAGWATI P.SARKAR, RUMA
Owner ALCON RES LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com