Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Liquid chromatography component

a technology of liquid chromatography and component, which is applied in the direction of separation process, ion-exchanger, instruments, etc., can solve the problems of affecting the measurement or analysis, changing the supplied liquid pressure, and increasing the supplied liquid pressure, and achieve excellent separation performan

Inactive Publication Date: 2012-03-22
YOTANI TAKUYA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0046]The present invention provides a liquid chromatography component including a column and a prefilter, wherein the component is hard to cause an increase in supplied liquid pressure even if the measurement of a sample is repeated, and wherein the prefilter requires replacement at almost the same frequency as the column does. The present invention also provides a liquid chromatography component including a column and a prefilter, wherein the column and the prefilter are integrated with each other, require no complicated replacement operation, and show excellent separation performance.

Problems solved by technology

These foreign substances are adsorbed on the surface of filler particles filled in the column or to a detector cell, and as a result, may adversely affect the measurement or analysis.
However, when the filtration efficiency of the filters is increased in order to more efficiently capture the foreign substances, the foreign substances may more easily clog the filters to cause the change in the supplied liquid pressure.
Particularly when a large number of samples are continuously measured as in analysis of hemoglobins or when a sample high in foreign substances like a hemolyzed blood sample is measured, the foreign substances clog the filter and often cause an increase in the supplied liquid pressure.
The change in the supplied liquid pressure may lead to a failure in accurate and quick measurement or analysis of the sample.
However, when the filtration area or the porosity of the filter is increased too much, the sample or the mobile phase in the filter may be diffused too much, which reduces the accuracy of the measurement or analysis.
However, these ideas have been established by taking only the filter into consideration, and no studies have been made covering the column where the clogging attributed to the foreign substances poses a problem as in the filter.
Thus, the filters require the replacement more often than the column does, which is a significant burden in terms of operation and cost.Patent Document 1: Japanese Kokai Publication No.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liquid chromatography component
  • Liquid chromatography component

Examples

Experimental program
Comparison scheme
Effect test

example 1

(1) Preparation of Prefilter

[0048]A sintered stainless-steel fiber filter sheet with a thickness of 0.4 mm and a porosity of 70% was punched into a circular shape with a diameter of 9.0 mm to give a sintered stainless-steel fiber filter with a filtration area of 63.59 mm2. The sintered stainless-steel fiber filter sheet had a three-layer structure composed of: a filter layer (outer layer 1) with a pore diameter of 12 μm and a thickness of 0.1 mm; a filter layer (inner layer) with a pore diameter of 3 μm and a thickness of 0.2 mm; and a filter layer (outer layer 2) with a pore diameter of 12 μm and a thickness of 0.1 mm, stacked in this order. The obtained filter was subjected to a blocking treatment with bovine serum albumin, thereby preventing non-specific adsorption of hemoglobins.

[0049]The surface-treated filter was secured with a polytetrafluoroethylene packing and then housed in a polyether ether ketone holder with a thread portion that can be connected to a channel. Thus, a pr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The present invention aims to provide a liquid chromatography component including a column and a prefilter, which is hard to cause an increase of supplied liquid pressure even when the measurement of a sample is repeated. The present invention is a liquid chromatography component, which includes: a column with filler particles filled therein; and a prefilter, the filler particles having an average particle size in the range of 2 to 20 μm, the prefilter having a filtering particle size in the range of ⅙ to ⅓ of the average particle size of the filler particles.

Description

TECHNICAL FIELD[0001]The present invention relates to a liquid chromatography component including: a column with filler particles filled therein; and a prefilter, wherein the component is hard to cause an increase in the supplied liquid pressure even when the measurement of a sample is repeated. The present invention also relates to a liquid chromatography component including: a column with filler particles filled therein; and a prefilter, wherein the prefilter requires replacement at almost the same frequency as the column does. Further, the present invention relates to a liquid chromatography component including: a column with filler particles filled therein; and a prefilter, wherein the column and the prefilter are integrated with each other, require no complicated replacement operation, and show excellent separation performance.BACKGROUND ART[0002]In the fields of organic chemistry, biochemistry, medicine, and the like, liquid chromatography has been widely used for measurement ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): B01D15/10
CPCB01D15/22B01J20/28004B01J2220/54G01N1/40G01N30/14G01N2030/524G01N30/603G01N30/6069G01N2030/085G01N2030/146G01N30/465
Inventor YOTANI, TAKUYA
Owner YOTANI TAKUYA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com