Plastic container comprising cyclic polyolefin layer

Inactive Publication Date: 2010-12-23
MITSUBISHI TANABE PHARMA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]It is an object of the present invention to provide a plastic container which suppresses a reduction in the content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container, and a multilayered film used for the aforementioned container.Means for Solving the Problems

Problems solved by technology

However, cyclic polyolefin is rigid and fragile, and further, it is poor in terms of heat-sealing properties.
Thus, cyclic polyolefin has been problematic in that a practical bag cannot be directly formed with the cyclic polyolefin itself.
Moreover, if a constituted multilayered film is rigid and inflexible, it causes problems such as low shock resistance and poor handling ability during the filling of a container with a medicament.
However, a plastic container capable of suppressing a reduction in the content of Edaravone due to adhesion of Edaravone to the plastic container has not yet been disclosed.

Method used

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  • Plastic container comprising cyclic polyolefin layer
  • Plastic container comprising cyclic polyolefin layer
  • Plastic container comprising cyclic polyolefin layer

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0072]A solution obtained by diluting commercially available Radicut (registered trademark) injection 30 mg (manufactured and distributed by Mitsubishi Tanabe Pharma Corporation) with 100 mL of a normal saline was filled into an infusion bag formed with each of various types of films A01 to A05 and Comparative Example 1 shown in Table 1, and it was then sterilized (115° C., 30 minutes). The content of a main component (Edaravone) was measured before and after the sterilization. The results are shown in Table 2. In the case of using a film comprising a cyclic polyolefin polymer or a cyclic polyolefin copolymer as a barrier layer, a significant reduction in the content of the component was not observed after the sterilization. On the other hand, in the case of using a film constituted only with polypropylene (ZELAS (registered trademark) RT-267A-1, MC717, 7023), a reduction in the content of the component was observed after sterilization.

TABLE 2Medicament adsorption on bag during ster...

example 2

[0074]A solution obtained by diluting commercially available Radicut (registered trademark) injection 30 mg (manufactured and distributed by Mitsubishi Tanabe Pharma Corporation) with 100 mL of a normal saline was filled into an infusion bag formed with each of various types of films of C01, C02 and Comparative Example 1 shown in Table 1, and it was then sterilized (115° C., 30 minutes). Thereafter, a severe test (60° C., 4 weeks) was carried out on each sample wrapped with a second wrapping material containing AGELESS as an oxygen absorber and having a suppressed gas permeability, which had been formed by silica evaporation. As shown in Table 4, in the case of the bag of Comparative Example 1, a reduction in the content of the component was observed over time. However, such reduction in the content of the component was not observed in the case of the bags of C01 and C02.

TABLE 4Severe stability test of bags containing COP as barrier layers (60° C.)AfterAfterfillingsterilizationWeek ...

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Abstract

The present invention provides and a plastic container and multilayered films, which comprises a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and which further comprises a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer. The plastic container of the present invention can suppresses a reduction in the medicament content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container.

Description

TECHNICAL FIELD[0001]The present invention relates to a plastic container suitable for containing a liquid-state medicament and a multilayered film used for this container.BACKGROUND ART[0002]A reduction in the content of a certain kind of medicament is suppressed using a container composed of cyclic polyolefin. The suppression of a reduction in the content of a certain kind of medicament is disclosed in JP Patent Publication (Kokai) No. 5-293159 A (1993) (Patent Document 1) and JP Patent Publication (Kokai) No. 2003-24415 A (Patent Document 2), for example. However, cyclic polyolefin is rigid and fragile, and further, it is poor in terms of heat-sealing properties. Thus, cyclic polyolefin has been problematic in that a practical bag cannot be directly formed with the cyclic polyolefin itself. In order to solve this problem, JP Patent Publication (Kokai) No. 2002-301796 A (Patent Document 3) and JP Patent Publication (Kohyo) No. 2005-525952 A (Patent Document 4), for example, have p...

Claims

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Application Information

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IPC IPC(8): B65D6/00B32B27/08
CPCA61J1/10A61K9/0019Y10T428/2826B32B27/30B32B27/32A61K31/4152A61P1/04A61P3/08A61P3/10A61P25/28A61P39/06B32B27/08B32B27/302B32B27/325B32B2250/24B32B2270/00B32B2307/30B32B2307/308B32B2307/31B32B2307/412B32B2307/50B32B2307/51B32B2307/546B32B2307/558B32B2307/7242B32B2307/7265B32B2439/80A61J1/1468
Inventor OZAKI, KAZUHIKOMATSUDA, MUNETOMONISHIMURA, TETSUROUTAKAYANAGI, KENJIROUKANEKO, HIROSHI
Owner MITSUBISHI TANABE PHARMA CORP
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