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Adsorption column for purifying body fluid

a technology for purifying body fluid and column, which is applied in the direction of moving filter element filter, filtration separation, separation process, etc., can solve the problems of increasing the risk of arteriosclerosis, increasing the risk of myocardial infarction and cerebral infarction, and reducing the effective area of micropores, so as to reduce the efficiency of body fluid purification, the effect of reducing the effective area of the micropor

Inactive Publication Date: 2010-11-04
REI MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]Fifthly, because a polymer support such as a porous cellulose gel contains a trace amount of additives and the like, adsorption of proteins in the blood and activation of a blood coagulation mechanism are promoted.
[0037]Further, according to the above-described adsorption column for body fluid purification of the sixth characteristic, it is possible to provide an adsorption column suitable for a case in which the plasma obtained after separating blood cell components from the blood is used as a body fluid containing a substance to be adsorbed.

Problems solved by technology

Among lipoproteins present in the blood, LDL contains cholesterol in abundance, and it is well known that hyper-low-density-lipoproteinemia, which is manifested as an elevation in the blood concentration of LDL, increases a risk of arteriosclerosis and increases risks of myocardial infarction and cerebral infarction.
An LDL apheresis treatment is practiced as one of the treatment methods for hyper-low-density-lipoproteinemia; however, a current situation is that it is applied exclusively to severely affected patients who are no longer responsive to drug therapy among patients with familial (hereditary) hyper-low-density-lipoproteinemia, obstructive arteriosclerosis, focal glomerulosclerosis, and the like, due to high medical costs and great burden imposed on the patients.

Method used

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  • Adsorption column for purifying body fluid
  • Adsorption column for purifying body fluid
  • Adsorption column for purifying body fluid

Examples

Experimental program
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first embodiment

[0052]As shown in FIG. 1, an apparatus of the present invention 10 is constituted in such a way that a columnar adsorbent 1 is contained in a cylindrical container 2. Openings 3 and 4 are each formed in each of the end surfaces of the cylindrical container 2, and the opening 3 serves as an inlet for a body fluid to be treated (postulated to be the plasma in the present embodiment), while the other opening 4 serves as an outlet for a treated body fluid.

[0053]The adsorbent 1, which is a major component part of the apparatus of the present invention 10, is, as schematically shown in FIG. 2, provided by modifying the surface of an inorganic porous support 5, which is formed in a columnar shape, with a functional group 6 which specifically binds to a substance to be adsorbed and immobilizing the functional group 6 thereon. In the present embodiment, LDL in the blood is postulated to be the substance to be adsorbed, and as the functional group 6, dextran sulfate or a salt thereof, a polya...

second embodiment

[0078]A second embodiment of the apparatus of the present invention is described. As shown in FIG. 12, an apparatus of the present invention 20 of a second embodiment is constituted in such a way that a cylindrical adsorbent 11 is contained in a cylindrical container 12. Openings 13 and 14 are each formed in each of end surfaces of the cylindrical container 12, and the opening 13 serves as an inlet for a body fluid to be treated (postulated to be the blood in the present embodiment), while the other opening 14 serves as an outlet for a treated body fluid.

[0079]As shown in FIG. 12, a cylindrical outer lateral surface 11a of the adsorbents 11 is spaced from an inner wall surface of the cylindrical container 12, and therebetween a channel 15 is formed for a body fluid (postulated to be the plasma here) which has passed through the adsorbent 11. Also, a cylindrical inner space of the adsorbent 11 serves as a channel 16 for a body fluid (blood) which does not pass through the adsorbent 1...

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Abstract

Provided is an absorption column for body fluid purification by which the saturated adsorption amount of a substance to be adsorbed can be increased or the time required for reaching the saturated adsorption can be shortened, and therefore, the column capacity can be considerably reduced and the treatment time can be considerably shortened. The adsorption column having functional groups 6 specifically binding to a substance to be adsorbed including at least low density lipoprotein, immobilized on the surface of a porous support 5. The porous support 5 has double-pore structure comprising: a skeleton 7 made of a silica gel or silica glass having a three-dimensional network structure; through-pores 8 of an average diameter measured by the mercury intrusion method of 1 μm or more but less than 4 μm and having a three-dimensional network structure, which are formed in the voids of the skeleton; and micropores 9 having an average diameter measured by the mercury intrusion method larger than the grain diameter of the substance to be adsorbed, which are dispersedly formed on the surface of the skeleton.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a National Phase filing under 35 U.S.C. §371 of International Application No. PCT / JP2008 / 066179 filed on Sep. 8, 2008, and which claims priority to Japanese Patent Application No. 2007-236564 filed on Sep. 12, 2007.TECHNICAL FIELD[0002]The present invention relates to an adsorption column for body fluid purification provided as a porous support having a functional group which binds specifically to a substance to be adsorbed immobilized on the surface thereof. Particularly, the present invention relates to an adsorption column for an apheresis treatment, which aims to remove a predisposing factor such as LDL (low-density lipoprotein) in the blood by adsorption.BACKGROUND ART[0003]An apheresis treatment is a treatment method intended to ameliorate a pathological condition by removing humoral factors (such as a protein, an antibody present in the blood as a conjugate with a protein, and an immune-related substance includi...

Claims

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Application Information

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IPC IPC(8): B01D15/22
CPCA61M1/3679B01J20/3204B01J20/327B01J20/3274B01J20/328B01J20/28085B01J20/2808B01J20/28095B01J20/103B01J20/28083B01J2220/58
Inventor IPPOMMATSU, MASAMICHIKURUSU, CHIEMIYAMOTO, RIICHIISHII, SAYAKANAKANISHI, KAZUKIMINAKUCHI, HIROYOSHIYANO, KEIKO
Owner REI MEDICAL
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