Equal-containing fermentation product of soybean embryonic axis, and method for production thereof

a technology of soybean embryonic axis and soybean hypocotyl, which is applied in the field of fermented soybean hypocotyl containing equol, can solve the problems that the desired useful benefits based on the action of equol cannot be sufficiently expected by ingesting the fermented product, and about 50% of japanese are not able to produce equol, etc., to achieve superior equol-derived active physiological effects, reduce the amount of allergen

Inactive Publication Date: 2009-12-17
OTSUKA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0035]The fermented soybean hypocotyl material of the invention contains equol and other active ingredients, such as isoflavones and saponins, and can thereby find a variety of applications in the food, pharmaceutical, cosmetic and other fields. The fermented soybean hypocotyl material of the invention, in particular, has a significantly higher equol content than those of the materials obtained by fermenting a raw material containing daidzein compounds such as soybean, Ge Gen Tang (Chinese traditional medicine, also known as Kakkonto), red globe grapes, alfalfa, and th

Problems solved by technology

That is, about 50% of Japanese are not able to produce equol (non-equol-producing individuals).
Such an individual cannot enjoy useful physiological benefits based on the action of equol even if they ingest soybeans and processed soybean foods.
However, simply subjecting the above-mentioned starting materials containing daidzein compounds to fermentation treatment by using equol-producing bacteria cannot yield sufficient amount of equol in the fermented product, and there has been the problem that desired useful benefits based on the action of equol cannot be sufficiently expected by ingesting the fermented product as

Method used

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  • Equal-containing fermentation product of soybean embryonic axis, and method for production thereof
  • Equal-containing fermentation product of soybean embryonic axis, and method for production thereof
  • Equal-containing fermentation product of soybean embryonic axis, and method for production thereof

Examples

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examples

[0072]The present invention is described in detail with reference to Test Examples, Examples, etc. below, but is not limited to these examples.

examples 1 to 3

[0073]Powdered soybean hypocotyls, arginine, and water were mixed in such a manner that the compositions of the mixture was as shown in Table 1 to prepare soybean hypocotyl solutions. Into 5 ml samples of the soybean hypocotyl solution was inoculated Lactococcus 20-92 (FERM BP-10036; Lactococcus garvieae), and subjected to static cultivation at 37° C. for 96 hours under anaerobic conditions. After cultivation, the resulting culture (fermented liquids) were sterilized by heating at 100° C. for one minute, subsequently dried at 80° C., and further powdered using a homogenizer, thereby obtaining powdered fermented soybean hypocotyl materials.

[0074]Table 1 shows equol concentrations in culture 96 hours after cultivation. Table 1 also shows viable bacterial counts and pH of culture media 96 hours after cultivation, yields of the powdered fermented soybean hypocotyl materials, and equol concentrations in the powdered fermented soybean hypocotyl materials. The results established that ferm...

example 4

[0075]Lactococcus 20-92 (FERM BP-10036; Lactococcus garvieae) was inoculated into 5 ml of a soybean hypocotyl solution containing 10 wt. % of powered soybean hypocotyls and 0.1 wt. % of L-arginine, and subjected to static cultivation at 37° C. for 96 hours under anaerobic conditions. After cultivation, the resulting culture (fermented liquid) was sterilized by heating at 100° C. for one minute, then dried at 80° C., and further powdered using a homogenizer, thereby obtaining a powered fermented soybean hypocotyl material.

[0076]The powdered soybean hypocotyls used as starting materials (referred to as “pre-fermentation” in Tables 2 and 3) and the obtained powdered fermented soybean hypocotyl material (referred to as “post-fermentation” in Tables 2 and 3) were analyzed for compositional components. Table 2 shows the analytical results for soybean isoflavones, and Table 3 shows the analytical results for nutritional components. These results also established that fermented soybean hypo...

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Abstract

An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc.
The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.

Description

TECHNICAL FIELD[0001]The present invention relates to fermented soybean hypocotyl containing equol and a method of producing the same.BACKGROUND ART[0002]Isoflavones (soybean isoflavones: daidzein, genistein, glycitein) contained in soybeans have structures similar to estradiol, and have anti-estrogen actions associated with biding to estrogen receptors (hereinafter referred to as ER) and estrogen-like actions. The epidemiological studies and intervention studies of soybean isoflavones that have been done before suggest their preventive effects due to their anti-estrogen actions on breast cancer, prostate cancer and other hormone-dependent cancers and improving effects due to estrogen-like actions on menopausal disorders, postmenopausal osteoporosis and hyperlipidemia.[0003]Recently, it has been pointed out that the active principle of the physiological effects of these soybean isoflavones may be a metabolite of daidzein, equol. More specifically, it has been reported that equol has...

Claims

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Application Information

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IPC IPC(8): A61K36/48A01H5/00C12P1/04A61P19/10A61P3/00A61P15/00A23L11/00A23L11/20A23L33/00A23L33/10A23L33/135A61K8/9789A61K8/99A61K31/352A61K35/74A61K35/744A61K131/00A61P3/04A61P3/06A61P13/08A61P15/12
CPCA61K2800/85A61Q19/10A61Q19/02A61Q19/00A61K8/97A23L1/2008A23L1/3002A23V2002/00A61K8/498A23V2250/21172A23V2250/5488A23V2200/3262A23L33/10A61K31/352A61K36/48A61K2236/19A23L11/50A23V2200/30A23L33/105A61K8/9789A61P1/00A61P13/08A61P15/00A61P15/12A61P19/10A61P25/24A61P3/00A61P35/00A61P3/04A61P3/06A61P5/30A61P5/32A61P7/10A23V2400/21A23L11/07A23V2250/0636
Inventor KIMURA, HIROYUKIYAMAUCHI, TAKESHIUENO, TOMOMISUZUKI, TOSHIMITADANO, KENTAROSATO, IKUTAROUCHIYAMA, SHIGETOOONO, MASAHIROMIZUNO, MASATOSHI
Owner OTSUKA PHARM CO LTD
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